Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease.

Authors: Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI

Nature communications. 2022 Jul 6;13(1):3897

Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease.

Authors: Rudilosso S, Chui E, Stringer MS, Thrippleton M, Chappell F, Blair G, GarcÃa DJ, Doubal F, Hamilton I, Kopczak A, Ingrish M, Kerkhofs D, Backes WH, Staals J, van Oostenbrugge R, Duering M, Dichgans M, Wardlaw JM, SVDs@Target Investigators

Neurology. 2022 May 23;99(5):e440-52

Contribution of white matter hyperintensities to ventricular enlargement in older adults.

Authors: Jochems ACC, Muñoz Maniega S, Del C Valdés Hernández M, Barclay G, Anblagan D, Ballerini L, Meijboom R, Wiseman S, Taylor AM, Corley J, Chappell FM, Backhouse EV, Stringer MS, Dickie DA, Bastin ME, Deary IJ, Cox SR, Wardlaw JM

NeuroImage. Clinical. 2022;34:103019

Enhanced Vascular Contractility Following Secondhand Smoke Exposure: A Pathological "Double-hit" to Critical Smooth Muscle Ion Channels.

Authors: Klug NR, Nelson MT

Function (Oxford, England). 2022;3(1):zqab061

Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases.

Authors: Wardlaw JM, Liebeskind DS

Stroke. 2022 Apr;53(4):1399-1401

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments.

Authors: Habota T, Sandu AL, Waiter GD, McNeil CJ, Steele JD, Macfarlane JA, Whalley HC, Valentine R, Younie D, Crouch N, Hawkins EL, Hirose Y, Romaniuk L, Milburn K, Buchan G, Coupar T, Stirling M, Jagpal B, MacLennan B, Priba L, Harris MA, Hafferty JD, Adams MJ, Campbell AI, MacIntyre DJ, Pattie A, Murphy L, Reynolds RM, Elliot R, Penton-Voak IS, Munafò MR, Evans KL, Seckl JR, Wardlaw JM, Lawrie SM, Haley CS, Porteous DJ, Deary IJ, Murray AD, McIntosh AM

Wellcome open research. 2019;4:185

CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis.

Authors: Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C

The Journal of clinical investigation. 2022 Apr 15;132(8)

Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning.

Authors: Sundaresan V, Arthofer C, Zamboni G, Dineen RA, Rothwell PM, Sotiropoulos SN, Auer DP, Tozer DJ, Markus HS, Miller KL, Dragonu I, Sprigg N, Alfaro-Almagro F, Jenkinson M, Griffanti L

Frontiers in neuroinformatics. 2021;15:777828

Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke.

Authors: Clancy U, Makin SDJ, McHutchison CA, Cvoro V, Chappell FM, Hernández MDCV, Sakka E, Doubal F, Wardlaw JM

Neurology. 2022 Apr 5;98(14):e1459-e1469

Diagnosing vascular cognitive impairment: Current challenges and future perspectives.

Authors: Biesbroek JM, Biessels GJ

International journal of stroke : official journal of the International Stroke Society. 2022 Jan 30;:17474930211073387

Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.

Authors: Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M

Acta neuropathologica communications. 2022 Jan 24;10(1):6

Blood Pressure Complexity Discriminates Pathological Beat-to-Beat Variability as a Marker of Vascular Aging.

Authors: Lee YK, Mazzucco S, Rothwell PM, Payne SJ, Webb AJS

Journal of the American Heart Association. 2022 Feb;11(3):e022865

Blood-based epigenome-wide analyses of cognitive abilities.

Authors: McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA, Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans KL, Deary IJ, Cox SR, Robinson MR, Marioni RE

Genome biology. 2022 Jan 17;23(1):26

Non-Invasive Assessment of Damping of Blood Flow Velocity Pulsatility in Cerebral Arteries With MRI.

Authors: Arts T, Onkenhout LP, Amier RP, van der Geest R, van Harten T, Kappelle J, Kuipers S, van Osch MJP, van Bavel ET, Biessels GJ, Zwanenburg JJM, Heart-Brain Connection Consortium

Journal of magnetic resonance imaging : JMRI. 2022 Jun;55(6):1785-1794

Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI.

Authors: Arts T, Siero JCW, Biessels GJ, Zwanenburg JJM

Journal of magnetic resonance imaging : JMRI. 2021 Jan;53(1):234-241

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.

Authors: Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ

The Lancet. Neurology. 2021 Jun;20(6):448-459

Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease.

Authors: de Brito Robalo BM, Biessels GJ, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Yin Ka Lam B, Leemans A, Mok V, Onkenhout LP, van den Brink H, de Luca A

NeuroImage. Clinical. 2021;32:102886

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study.

Authors: Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M

Stroke. 2022 Apr;53(4):e130-e135

Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors.

Authors: Stringer MS, Heye AK, Armitage PA, Chappell F, Valdés Hernández MDC, Makin SDJ, Sakka E, Thrippleton MJ, Wardlaw JM

NeuroImage. Clinical. 2021;32:102883

Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial.

Authors: Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flaherty K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM

Stroke. 2022 Jan;53(1):29-33

Aortic Stiffness, Pulse Pressure, and Cerebral Pulsatility Progress Despite Best Medical Management: The OXVASC Cohort.

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM, OXVASC Study Cohort

Stroke. 2022 Apr;53(4):1310-1317

Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

Authors: Jiménez-Sánchez L, Hamilton OKL, Clancy U, Backhouse EV, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM

Frontiers in neurology. 2021;12:756887

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.

Authors: Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ

Alzheimer's & dementia (Amsterdam, Netherlands). 2021;13(1):e12240

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies.

Authors: Backhouse EV, Shenkin SD, McIntosh AM, Bastin ME, Whalley HC, Valdez Hernandez M, Muñoz Maniega S, Harris MA, Stolicyn A, Campbell A, Steele D, Waiter GD, Sandu AL, Waymont JMJ, Murray AD, Cox SR, de Rooij SR, Roseboom TJ, Wardlaw JM

Brain : a journal of neurology. 2021 Dec 31;144(12):3769-3778

Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.

Authors: Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M

Brain : a journal of neurology. 2022 Apr 18;145(2):787-797

Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies.

Authors: Wardlaw JM, Benveniste H, Williams A

Annual review of physiology. 2022 Feb 10;84:409-434

Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities.

Authors: Malik R, Beaufort N, Frerich S, Gesierich B, Georgakis MK, Rannikmäe K, Ferguson AC, Haffner C, Traylor M, Ehrmann M, Sudlow CLM, Dichgans M

Brain : a journal of neurology. 2021 Oct 22;144(9):2670-2682

Genetics, Genomics, and Precision Medicine.

Authors: Meschia JF, Dichgans M

Stroke. 2021 Oct;52(10):3385-3387

Comparison of domain adaptation techniques for white matter hyperintensity segmentation in brain MR images.

Authors: Sundaresan V, Zamboni G, Dinsdale NK, Rothwell PM, Griffanti L, Jenkinson M

Medical image analysis. 2021 Dec;74:102215

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease.

Authors: Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson MT

The Journal of clinical investigation. 2021 Sep 15;131(18)

Stroke Genetics: Turning Discoveries into Clinical Applications.

Authors: Dichgans M, Beaufort N, Debette S, Anderson CD

Stroke. 2021 Aug;52(9):2974-2982

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

Authors: Traylor M, Malik R, Gesierich B, Dichgans M

Brain : a journal of neurology. 2022 Mar 29;145(1):295-304

Triplanar ensemble U-Net model for white matter hyperintensities segmentation on MR images.

Authors: Sundaresan V, Zamboni G, Rothwell PM, Jenkinson M, Griffanti L

Medical image analysis. 2021 Oct;73:102184

Blood Pressure Control and Recurrent Stroke After Intracerebral Hemorrhage in 2002 to 2018 Versus 1981 to 1986: Population-Based Study.

Authors: Li L, Zuurbier SM, Kuker W, Warlow CP, Rothwell PM

Stroke. 2021 Oct;52(10):3243-3248

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

Authors: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ

Translational psychiatry. 2021 Jul 6;11(1):376

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study.

Authors: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Nov;41(11):3127-3138

Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model.

Authors: Koide M, Ferris HR, Nelson MT, Wellman GC

Frontiers in physiology. 2021;12:688468

Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study.

Authors: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ

GeroScience. 2021 Aug;43(4):1643-1652

A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease.

Authors: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM

Frontiers in physiology. 2021;12:644837

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.

Authors: Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Malik R, Ewers M

Nature communications. 2021 Jun 22;12(1):3825

Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage.

Authors: Wiegertjes K, Dinsmore L, Drever J, Hutchison A, Stephen J, Valdés Hernández MC, Bhatnagar P, Minks DP, Rodrigues MA, Werring DJ, de Leeuw FE, Klijn CJ, Al-Shahi Salman R, White PM, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2021 Sep;92(9):950-955

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle.

Authors: Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S

Nature communications. 2021 Jun 1;12(1):3296

Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: A systematic review.

Authors: Humphreys CA, Smith C, Wardlaw JM

Neuropathology and applied neurobiology. 2021 Dec;47(7):910-930

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort.

Authors: Hamilton O, Cox SR, Ballerini L, Bastin ME, Corley J, Gow AJ, Muñoz Maniega S, Redmond P, Valdés Hernández MDC, Wardlaw JM, Deary IJ

Neurobiology of aging. 2021 Sep;105:25-34

Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.

Authors: Stewart CR, Stringer MS, Shi Y, Thrippleton MJ, Wardlaw JM

Frontiers in neurology. 2021;12:647848

Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study.

Authors: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M

Translational psychiatry. 2021 May 17;11(1):291

Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI.

Authors: Arts T, Meijs TA, Grotenhuis H, Voskuil M, Siero J, Biessels GJ, Zwanenburg J

Frontiers in neuroscience. 2021;15:665480

Fluid transport in the brain.

Authors: Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews. 2022 Apr 1;102(2):1025-1151

Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI.

Authors: Sloots JJ, Biessels GJ, de Luca A, Zwanenburg JJM

NeuroImage. 2021 Aug 1;236:118078

Improving Clinical Detection of Acute Lacunar Stroke: Analysis From the IST-3.

Authors: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM, Third International Stroke Trial Collaborators

Stroke. 2020 May;51(5):1411-1418

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases.

Authors: Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U, Chappell FM, Brown R, Jaime Garcia D, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés-Hernández MC, Doubal FN, Wardlaw JM

Stroke. 2020 May;51(5):1503-1506

PIP(2) corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.

Authors: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 27;118(17)

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses.

Authors: Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D

Hypertension (Dallas, Tex. : 1979). 2021 Jun;77(6):2004-2013

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3.

Authors: Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM

European stroke journal. 2021 Mar;6(1):81-88

Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities.

Authors: Kerkhofs D, Wong SM, Zhang E, Staals J, Jansen JFA, van Oostenbrugge RJ, Backes WH

Neurology. 2021 Apr 27;96(17):e2192-e2200

Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.

Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

Frontiers in physiology. 2021;12:643468

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke.

Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

Frontiers in neurology. 2021;12:634460

Body Mass Index and Arterial Stiffness Are Associated With Greater Beat-to-Beat Blood Pressure Variability After Transient Ischemic Attack or Minor Stroke.

Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort

Stroke. 2021 Apr;52(4):1330-1338

Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.

Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

Stroke. 2021 Mar;52(3):931-936

Direct Measurement of Cerebrospinal Fluid Production in Mice.

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

A Case of Sporadic Cerebral Small Vessel Disease in an Identical Twin.

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus.

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2021 Feb;30(2):285-298

Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management.

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

Cerebral Amyloid Angiopathy: Still a Syndromal Diagnosis.

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Apr;17(4):665-685

Age and sex distribution of beat-to-beat blood pressure variability after transient ischemic attack and minor stroke: A population-based study.

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2021 Aug;16(6):683-691

Physiological determinants of residual cerebral arterial pulsatility on best medical treatment after TIA or minor stroke.

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun;41(6):1463-1471

Clinical management of cerebral small vessel disease: a call for a holistic approach.

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;134(2):127-142

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

Vascular control of the CO(2)/H(+)-dependent drive to breathe.

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease.

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity.

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

Circadian control of brain glymphatic and lymphatic fluid flow.

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke.

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis.

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes.

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

The Brain's Glymphatic System: Current Controversies.

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

Intracranial hemodynamic relationships in patients with cerebral small vessel disease.

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage.

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

Aquaporin 1 and the Na(+)/K(+)/2Cl(-) cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI.

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Small vessel diseases in a mechanistic perspective:Targets for Intervention – Affected pathways and mechanistic exploitation for prevention of stroke and dementia

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Publications with PubMed ID

Small vessel diseases in a mechanistic perspective:
Targets for Intervention – Affected pathways and mechanistic exploitation
for prevention of stroke and dementia