Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide.

Authors: Gladman JT, Corriveau RA, Debette S, Dichgans M, Greenberg SM, Sachdev PS, Wardlaw JM, Biessels GJ

Alzheimer's & dementia (New York, N. Y.). 2019;5:789-796

Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke.

Authors: Webb AJS, Paolucci M, Mazzucco S, Li L, Rothwell PM

Stroke. 2019 Dec 30;:STROKEAHA119027829

Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment.

Authors: Zhang CE, Staals J, van Oostenbrugge RJ, Vink H

Frontiers in neurology. 2019;10:1268

"A Step and a Ceiling": mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure-induced oxidative activation of PKG.

Authors: Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HT, Hill-Eubanks D, Eaton P, Nelson MT, Greenstein AS

Physiological reports. 2019 Nov;7(22):e14260

Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease.

Authors: Bernal J, Valdés-Hernández MDC, Escudero J, Viksne L, Heye AK, Armitage PA, Makin S, Touyz RM, Wardlaw JM

Magnetic resonance imaging. 2019 Nov 13;

Predictors of Lesion Cavitation After Recent Small Subcortical Stroke.

Authors: Gattringer T, Valdes Hernandez M, Heye A, Armitage PA, Makin S, Chappell F, Pinter D, Doubal F, Enzinger C, Fazekas F, Wardlaw JM

Translational stroke research. 2019 Nov 8;

Sleep and brain morphological changes in the eighth decade of life.

Authors: Aribisala BS, Riha RL, Valdes Hernandez M, Muñoz Maniega S, Cox S, Radakovic R, Taylor A, Pattie A, Corley J, Redmond P, Bastin ME, Starr J, Deary I, Wardlaw JM

Sleep medicine. 2019 Jul 24;

The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1.

Authors: Prestel M, Prell-Schicker C, Webb T, Malik R, Lindner B, Ziesch N, Rex-Haffner M, Röh S, Viturawong T, Lehm M, Mokry M, den Ruijter H, Haitjema S, Asare Y, Söllner F, Najafabadi MG, Aherrahrou R, Civelek M, Samani NJ, Mann M, Haffner C, Dichgans M

Stroke. 2019 Oct;50(10):2651-2660

Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease.

Authors: Wong SM, Backes WH, Drenthen GS, Zhang CE, Voorter PHM, Staals J, van Oostenbrugge RJ, Jansen JFA

Journal of magnetic resonance imaging : JMRI. 2019 Sep 4;

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals.

Authors: Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt SM, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M

Circulation research. 2019 Sep 27;125(8):773-782

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

Authors: Sweeney AM, Plá V, Du T, Liu G, Sun Q, Peng S, Plog BA, Kress BT, Wang X, Mestre H, Nedergaard M

Journal of visualized experiments : JoVE. 2019 Jul 29;(149)

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age.

Authors: Muñoz Maniega S, Meijboom R, Chappell FM, Valdés Hernández MDC, Starr JM, Bastin ME, Deary IJ, Wardlaw JM

Frontiers in neurology. 2019;10:784

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND).

Authors: Düzel E, Acosta-Cabronero J, Berron D, Biessels GJ, Björkman-Burtscher I, Bottlaender M, Bowtell R, Buchem MV, Cardenas-Blanco A, Boumezbeur F, Chan D, Clare S, Costagli M, de Rochefort L, Fillmer A, Gowland P, Hansson O, Hendrikse J, Kraff O, Ladd ME, Ronen I, Petersen E, Rowe JB, Siebner H, Stoecker T, Straub S, Tosetti M, Uludag K, Vignaud A, Zwanenburg J, Speck O

Alzheimer's & dementia (Amsterdam, Netherlands). 2019 Dec;11:538-549

Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding.

Authors: Sundaresan V, Zamboni G, Le Heron C, Rothwell PM, Husain M, Battaglini M, De Stefano N, Jenkinson M, Griffanti L

NeuroImage. 2019 Nov 15;202:116056

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial.

Authors: Appleton JP, Blair GW, Flaherty K, Law ZK, May J, Woodhouse LJ, Doubal F, Sprigg N, Bath PM, Wardlaw JM

Frontiers in neurology. 2019;10:723

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial.

Authors: Blair GW, Appleton JP, Flaherty K, Doubal F, Sprigg N, Dooley R, Richardson C, Hamilton I, Law ZK, Shi Y, Stringer MS, Thrippleton MJ, Boyd J, Shuler K, Bath PM, Wardlaw JM

EClinicalMedicine. 2019 May-Jun;11:34-43

Stroke genetics: discovery, biology, and clinical applications.

Authors: Dichgans M, Pulit SL, Rosand J

The Lancet. Neurology. 2019 Jun;18(6):587-599

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.

Authors: Wang M, Qin C, Luo X, Wang J, Wang X, Xie M, Hu J, Cao J, Hu T, Goldman SA, Nedergaard M, Wang W

Theranostics. 2019;9(15):4474-4493

Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition.

Authors: Valdés Hernández MDC, Ballerini L, Glatz A, Muñoz Maniega S, Gow AJ, Bastin ME, Starr JM, Deary IJ, Wardlaw JM

Brain imaging and behavior. 2019 Jun 27;

Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel.

Authors: Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M

Journal of the American College of Cardiology. 2019 Jul 2;73(25):3326-3344

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects.

Authors: Gill D, Georgakis MK, Koskeridis F, Jiang L, Feng Q, Wei WQ, Theodoratou E, Elliott P, Denny JC, Malik R, Evangelou E, Dehghan A, Dichgans M, Tzoulaki I

Circulation. 2019 Jul 23;140(4):270-279

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.

Authors: Mortensen KN, Sanggaard S, Mestre H, Lee H, Kostrikov S, Xavier ALR, Gjedde A, Benveniste H, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Aug 7;39(32):6365-6377

Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability.

Authors: McHutchison CA, Chappell FM, Makin S, Shuler K, Wardlaw JM, Cvoro V

Brain sciences. 2019 May 22;9(5)

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.

Authors: Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2019 Jun;15(6):840-858

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke.

Authors: Wyss A, Dawson J, Arba F, Wardlaw JM, Dickie DA

Stroke. 2019 May;50(5):1136-1139

Prognostic value of "tissue-based" definitions of TIA and minor stroke: Population-based study.

Authors: Hurford R, Li L, Lovett N, Kubiak M, Kuker W, Rothwell PM, Oxford Vascular Study.

Neurology. 2019 May 21;92(21):e2455-e2461

Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke.

Authors: Valdés Hernández MDC, Case T, Chappell FM, Glatz A, Makin S, Doubal F, Wardlaw JM

International journal of molecular sciences. 2019 Mar 14;20(6)

A prospective study of serum metabolites and risk of ischemic stroke.

Authors: Sun D, Tiedt S, Yu B, Jian X, Gottesman RF, Mosley TH, Boerwinkle E, Dichgans M, Fornage M

Neurology. 2019 Apr 16;92(16):e1890-e1898

MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease.

Authors: Thrippleton MJ, Blair GW, Valdes-Hernandez MC, Glatz A, Semple SIK, Doubal F, Vesey A, Marshall I, Newby DE, Wardlaw JM

International journal of molecular sciences. 2019 Feb 12;20(3)

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease.

Authors: Wong SM, Jansen JFA, Zhang CE, Hoff EI, Staals J, van Oostenbrugge RJ, Backes WH

Neurology. 2019 Apr 9;92(15):e1669-e1677

Dementia risk after transient ischaemic attack and stroke.

Authors: Dichgans M

The Lancet. Neurology. 2019 Mar;18(3):223-225

WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.

Authors: Georgakis MK, Duering M, Wardlaw JM, Dichgans M

Neurology. 2019 Mar 19;92(12):e1298-e1308

Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy.

Authors: Wollenweber FA, Opherk C, Zedde M, Catak C, Malik R, Duering M, Konieczny MJ, Pascarella R, Samões R, Correia M, Martí-Fàbregas J, Linn J, Dichgans M

Neurology. 2019 Feb 19;92(8):e792-e801

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors: Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S, Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

Neurology. 2019 Jan 16;

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.

Authors: Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M

Circulation. 2019 Jan 8;139(2):256-268

Role of Non-Coding RNAs in Stroke.

Authors: Tiedt S, Dichgans M

Stroke. 2018 Dec;49(12):3098-3106

Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.

Authors: McHutchison CA, Cvoro V, Makin S, Chappell FM, Shuler K, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2019 Apr;90(4):436-443

Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study.

Authors: Geurts LJ, Zwanenburg JJM, Klijn CJM, Luijten PR, Biessels GJ

Stroke. 2018 Dec 11;:STROKEAHA118022516

The glymphatic pathway in neurological disorders.

Authors: Rasmussen MK, Mestre H, Nedergaard M

The Lancet. Neurology. 2018 Nov;17(11):1016-1024

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Authors: Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH

Nature communications. 2018 Nov 19;9(1):4878

Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review.

Authors: Pellegrini E, Ballerini L, Hernandez MDCV, Chappell FM, González-Castro V, Anblagan D, Danso S, Muñoz-Maniega S, Job D, Pernet C, Mair G, MacGillivray TJ, Trucco E, Wardlaw JM

Alzheimer's & dementia (Amsterdam, Netherlands). 2018;10:519-535

Long-Term Premorbid Blood Pressure and Cerebral Small Vessel Disease Burden on Imaging in Transient Ischemic Attack and Ischemic Stroke.

Authors: Lau KK, Li L, Simoni M, Mehta Z, Küker W, Rothwell PM, Oxford Vascular Study.

Stroke. 2018 Sep;49(9):2053-2060

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow.

Authors: Shi Y, Thrippleton MJ, Blair GW, Dickie DA, Marshall I, Hamilton I, Doubal FN, Chappell F, Wardlaw JM

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020 Jan;40(1):85-99

Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension.

Authors: Uiterwijk R, Staals J, Huijts M, van Kuijk SMJ, de Leeuw PW, Kroon AA, van Oostenbrugge RJ

Journal of clinical hypertension (Greenwich, Conn.). 2018 Oct;20(10):1458-1463

Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke.

Authors: Tiedt S, Duering M, Barro C, Kaya AG, Boeck J, Bode FJ, Klein M, Dorn F, Gesierich B, Kellert L, Ertl-Wagner B, Goertler MW, Petzold GC, Kuhle J, Wollenweber FA, Peters N, Dichgans M

Neurology. 2018 Oct 2;91(14):e1338-e1347

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice.

Authors: Foulquier S, Namsolleck P, Van Hagen BT, Milanova I, Post MJ, Blankesteijn WM, Rutten BP, Prickaerts J, Van Oostenbrugge RJ, Unger T

Hypertension research : official journal of the Japanese Society of Hypertension. 2018 Oct;41(10):817-827

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke.

Authors: Loos CM, McHutchison C, Cvoro V, Makin SD, Staals J, Chappell F, Dennis MS, van Oostenbrugge RJ, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Jul;13(5):518-524

Development of stress-induced bladder insufficiency requires functional TRPV1 channels.

Authors: Tykocki NR, Heppner TJ, Erickson CS, van Batavia J, Vizzard MA, Nelson MT, Mingin GC

American journal of physiology. Renal physiology. 2018 Dec 1;315(6):F1583-F1591

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.

Authors: Harraz OF, Longden TA, Hill-Eubanks D, Nelson MT

eLife. 2018 Aug 7;7

Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis.

Authors: Backhouse EV, McHutchison CA, Cvoro V, Shenkin SD, Wardlaw JM

PloS one. 2018;13(7):e0200525

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke.

Authors: Liu B, Lau KK, Li L, Lovelock C, Liu M, Kuker W, Rothwell PM

Stroke. 2018 Apr;49(4):899-904

Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging.

Authors: Zhang CE, Wong SM, Uiterwijk R, Backes WH, Jansen JFA, Jeukens CRLPN, van Oostenbrugge RJ, Staals J

Brain imaging and behavior. 2019 Apr;13(2):389-395

Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

Authors: Cox SR, Allerhand M, Ritchie SJ, Muñoz Maniega S, Valdés Hernández M, Harris SE, Dickie DA, Anblagan D, Aribisala BS, Morris Z, Sherwood R, Abbott NJ, Starr JM, Bastin ME, Wardlaw JM, Deary IJ

Neurobiology of aging. 2018 Sep;69:274-282

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke.

Authors: Makin SD, Doubal FN, Quinn TJ, Bath PM, Dennis MS, Wardlaw JM

European stroke journal. 2018 Mar;3(1):66-73

William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable.

Authors: Wardlaw JM

Stroke. 2018 Jul;49(7):1770-1775

Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Authors: Loos CMJ, Makin SDJ, Staals J, Dennis MS, van Oostenbrugge RJ, Wardlaw JM

Stroke. 2018 May;49(5):1183-1188

Time course of blood pressure control prior to lacunar TIA and stroke: Population-based study.

Authors: Li L, Welch SJV, Gutnikov SA, Mehta Z, Rothwell PM, Oxford Vascular Study.

Neurology. 2018 May 15;90(20):e1732-e1741

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease.

Authors: Bailey EL, McBride MW, McClure JD, Beattie W, Graham D, Dominiczak AF, Smith C, Wardlaw JM

Clinical science (London, England : 1979). 2018 Jun 29;132(12):1315-1328

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion.

Authors: Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2018 Apr 10;115(15):E3569-E3577

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke.

Authors: Ratelade J, Mezouar N, Domenga-Denier V, Rochey A, Plaisier E, Joutel A

The Journal of pathology. 2018 Apr;244(4):408-420

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors: Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, AFGen Consortium., Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium., International Genomics of Blood Pressure (iGEN-BP) Consortium., INVENT Consortium., STARNET., Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, BioBank Japan Cooperative Hospital Group., COMPASS Consortium., EPIC-CVD Consortium., EPIC-InterAct Consortium., International Stroke Genetics Consortium (ISGC)., METASTROKE Consortium., Neurology Working Group of the CHARGE Consortium., NINDS Stroke Genetics Network (SiGN)., UK Young Lacunar DNA Study., MEGASTROKE Consortium., Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M

Nature genetics. 2018 Apr;50(4):524-537

Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension.

Authors: Uiterwijk R, Staals J, Huijts M, de Leeuw PW, Kroon AA, van Oostenbrugge RJ

Journal of clinical hypertension (Greenwich, Conn.). 2018 Feb;20(2):240-245

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury.

Authors: Dickie DA, Valdés Hernández MDC, Makin SD, Staals J, Wiseman SJ, Bastin ME, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Oct;13(8):849-856

Smooth muscle cells of intracranial vessels: from development to disease.

Authors: Frösen J, Joutel A

Cardiovascular research. 2018 Mar 15;114(4):501-512

Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI - A proof of concept study.

Authors: Geurts LJ, Bhogal AA, Siero JCW, Luijten PR, Biessels GJ, Zwanenburg JJM

NeuroImage. 2018 May 15;172:470-477

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing.

Authors: Thrippleton MJ, Shi Y, Blair G, Hamilton I, Waiter G, Schwarzbauer C, Pernet C, Andrews PJ, Marshall I, Doubal F, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Feb;13(2):195-206

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke.

Authors: Webb AJS, Mazzucco S, Li L, Rothwell PM

Stroke. 2018 Jan;49(1):62-67

Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology.

Authors: Harper AM, Clayson L, Wardlaw JM, Valdés Hernández MDC, Alzheimer’s Disease Neuroimaging Initiative.

The Journal of international medical research. 2018 Sep;46(9):3518-3538

Correction: Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance.

Authors: González-Castro V, Valdés Hernández MDC, Chappell FM, Armitage PA, Makin S, Wardlaw JM

Clinical science (London, England : 1979). 2017 Dec 15;131(24):2959

Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke.

Authors: Zietemann V, Kopczak A, Müller C, Wollenweber FA, Dichgans M

Stroke. 2017 Nov;48(11):2952-2957

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Authors: Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM, Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).

Neurology. 2017 Oct 24;89(17):1829-1839

RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke.

Authors: Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M

Circulation research. 2017 Sep 29;121(8):970-980

White matter hyperintensity reduction and outcomes after minor stroke.

Authors: Wardlaw JM, Chappell FM, Valdés Hernández MDC, Makin SDJ, Staals J, Shuler K, Thrippleton MJ, Armitage PA, Muñoz-Maniega S, Heye AK, Sakka E, Dennis MS

Neurology. 2017 Sep 5;89(10):1003-1010

Detection, risk factors, and functional consequences of cerebral microinfarcts.

Authors: van Veluw SJ, Shih AY, Smith EE, Chen C, Schneider JA, Wardlaw JM, Greenberg SM, Biessels GJ

The Lancet. Neurology. 2017 Sep;16(9):730-740

Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity.

Authors: Valdés Hernández MDC, González-Castro V, Chappell FM, Sakka E, Makin S, Armitage PA, Nailon WH, Wardlaw JM

Frontiers in neurology. 2017;8:327

Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis.

Authors: McHutchison CA, Backhouse EV, Cvoro V, Shenkin SD, Wardlaw JM

Epidemiology (Cambridge, Mass.). 2017 Jul;28(4):608-618

Advanced Neuroimaging of Cerebral Small Vessel Disease.

Authors: Blair GW, Hernandez MV, Thrippleton MJ, Doubal FN, Wardlaw JM

Current treatment options in cardiovascular medicine. 2017 Jul;19(7):56

Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function.

Authors: Povlsen GK, Longden TA, Bonev AD, Hill-Eubanks DC, Nelson MT

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Jul;36(7):1195-201

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Authors: Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL, Rothwell PM, Rosand J, Ellinor PT, Markus HS, Traylor M, WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia.

Stroke. 2017 Jun;48(6):1451-1456

MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension.

Authors: Uiterwijk R, Staals J, Huijts M, de Leeuw PW, Kroon AA, van Oostenbrugge RJ

Journal of hypertension. 2017 Jun;35(6):1263-1270

Vascular disease and neurodegeneration: advancing together.

Authors: The Lancet Neurology

The Lancet. Neurology. 2017 May;16(5):333

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.

Authors: Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT

Nature neuroscience. 2017 May;20(5):717-726

Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms.

Authors: Joutel A, Chabriat H

Clinical science (London, England : 1979). 2017 Apr 25;131(8):635-651

Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe.

Authors: Hawkins VE, Takakura AC, Trinh A, Malheiros-Lima MR, Cleary CM, Wenker IC, Dubreuil T, Rodriguez EM, Nelson MT, Moreira TS, Mulkey DK

eLife. 2017 Apr 7;6

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Authors: Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Mar 15;37(11):2870-2877

Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis.

Authors: Backhouse EV, McHutchison CA, Cvoro V, Shenkin SD, Wardlaw JM

Neurology. 2017 Mar 7;88(10):976-984

Genetic variation at 16q24.2 is associated with small vessel stroke.

Authors: Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S, METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium., Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS, International Stroke Genetics Consortium.

Annals of neurology. 2017 Mar;81(3):383-394

Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition.

Authors: Zhang CE, Wong SM, Uiterwijk R, Staals J, Backes WH, Hoff EI, Schreuder T, Jeukens CR, Jansen JF, van Oostenbrugge RJ

Stroke. 2017 Mar;48(3):658-663

Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study.

Authors: Chappell FM, Del Carmen Valdés Hernández M, Makin SD, Shuler K, Sakka E, Dennis MS, Armitage PA, Muñoz Maniega S, Wardlaw JM

Trials. 2017 Feb 21;18(1):78

Vascular Cognitive Impairment.

Authors: Dichgans M, Leys D

Circulation research. 2017 Feb 3;120(3):573-591

Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study.

Authors: Ghaznawi R, de Bresser J, van der Graaf Y, Zwartbol MH, Witkamp TD, Geerlings MI, Hendrikse J, SMART Study Group *.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018 Sep;38(9):1609-1617

Blood pressure variability and leukoaraiosis in acute ischemic stroke.

Authors: Dickie DA, Aribisala B, Mair G, Berge E, Lindley RI, Sandercock P, von Kummer R, von Heijne A, Peeters A, Cala L, Farrall A, Morris Z, Bradey N, Potter G, Adami A, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Jul;13(5):473-480

Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension.

Authors: Uiterwijk R, van Oostenbrugge RJ, Huijts M, De Leeuw PW, Kroon AA, Staals J

Frontiers in aging neuroscience. 2016;8:301

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.

Authors: METACOHORTS Consortium. Electronic address: joanna.wardlaw@ed.ac.uk., METACOHORTS Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2016 Dec;12(12):1235-1249

Prediction of 3-year clinical course in CADASIL.

Authors: Jouvent E, Duchesnay E, Hadj-Selem F, De Guio F, Mangin JF, Hervé D, Duering M, Ropele S, Schmidt R, Dichgans M, Chabriat H

Neurology. 2016 Oct 25;87(17):1787-1795

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

Authors: Khavandi K, Baylie RA, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD, Nelson MT, Greenstein AS

Science signaling. 2016 Oct 11;9(449):ra100

Shrinkage-mediated imaging of entire organs and organisms using uDISCO.

Authors: Pan C, Cai R, Quacquarelli FP, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A

Nature methods. 2016 Oct;13(10):859-67

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice.

Authors: Dalsgaard T, Sonkusare SK, Teuscher C, Poynter ME, Nelson MT

Scientific reports. 2016 Sep 22;6:33841

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.

Authors: Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A

eLife. 2016 Aug 1;5

Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.

Authors: Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT

The Journal of physiology. 2016 Jun 15;594(12):3271-85

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Welcome to SVDs@target:

A new Horizon 2020 project

Small vessel diseases in a mechanistic perspective:Targets for Intervention – Affected pathways and mechanistic exploitation for prevention of stroke and dementia

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Small vessel diseases in a mechanistic perspective:
Targets for Intervention – Affected pathways and mechanistic exploitation
for prevention of stroke and dementia