Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Authors: Loos CMJ, Makin SDJ, Staals J, Dennis MS, van Oostenbrugge RJ, Wardlaw JM

Stroke. 2018 May;49(5):1183-1188

Time course of blood pressure control prior to lacunar TIA and stroke: Population-based study.

Authors: Li L, Welch SJV, Gutnikov SA, Mehta Z, Rothwell PM, Oxford Vascular Study.

Neurology. 2018 May 15;90(20):e1732-e1741

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease.

Authors: Bailey EL, McBride MW, McClure JD, Beattie W, Graham D, Dominiczak AF, Smith C, Wardlaw JM

Clinical science (London, England : 1979). 2018 Apr 9;

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion.

Authors: Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2018 Apr 10;115(15):E3569-E3577

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke.

Authors: Ratelade J, Mezouar N, Domenga-Denier V, Rochey A, Plaisier E, Joutel A

The Journal of pathology. 2018 Apr;244(4):408-420

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors: Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dörr M, Engström G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, Minegishi N, Montaner J, Morris AP, Muiño E, Müller-Nurasyid M, Norrving B, Ogishima S, Parati EA, Peddareddygari LR, Pedersen NL, Pera J, Perola M, Pezzini A, Pileggi S, Rabionet R, Riba-Llena I, Ribasés M, Romero JR, Roquer J, Rudd AG, Sarin AP, Sarju R, Sarnowski C, Sasaki M, Satizabal CL, Satoh M, Sattar N, Sawada N, Sibolt G, Sigurdsson Á, Smith A, Sobue K, Soriano-Tárraga C, Stanne T, Stine OC, Stott DJ, Strauch K, Takai T, Tanaka H, Tanno K, Teumer A, Tomppo L, Torres-Aguila NP, Touze E, Tsugane S, Uitterlinden AG, Valdimarsson EM, van der Lee SJ, Völzke H, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, AFGen Consortium., Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium., International Genomics of Blood Pressure (iGEN-BP) Consortium., INVENT Consortium., STARNET., BioBank Japan Cooperative Hospital Group., COMPASS Consortium., EPIC-CVD Consortium., EPIC-InterAct Consortium., International Stroke Genetics Consortium (ISGC)., METASTROKE Consortium., Neurology Working Group of the CHARGE Consortium., NINDS Stroke Genetics Network (SiGN)., UK Young Lacunar DNA Study., MEGASTROKE Consortium., MEGASTROKE Consortium:.

Nature genetics. 2018 Apr;50(4):524-537

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke.

Authors: Liu B, Lau KK, Li L, Lovelock C, Liu M, Kuker W, Rothwell PM

Stroke. 2018 Apr;49(4):899-904

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury.

Authors: Dickie DA, Valdés Hernández MDC, Makin SD, Staals J, Wiseman SJ, Bastin ME, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Jan 1;:1747493018770222

Smooth muscle cells of intracranial vessels: from development to disease.

Authors: Frösen J, Joutel A

Cardiovascular research. 2018 Mar 15;114(4):501-512

Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI - A proof of concept study.

Authors: Geurts LJ, Bhogal AA, Siero JCW, Luijten PR, Biessels GJ, Zwanenburg JJM

NeuroImage. 2018 May 15;172:470-477

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing.

Authors: Thrippleton MJ, Shi Y, Blair G, Hamilton I, Waiter G, Schwarzbauer C, Pernet C, Andrews PJ, Marshall I, Doubal F, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Feb;13(2):195-206

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke.

Authors: Webb AJS, Mazzucco S, Li L, Rothwell PM

Stroke. 2018 Jan;49(1):62-67

Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology.

Authors: Harper AM, Clayson L, Wardlaw JM, Valdés Hernández MDC, Alzheimer’s Disease Neuroimaging Initiative.

The Journal of international medical research. 2018 Jan 1;:300060518755623

Correction: Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance.

Authors: González-Castro V, Valdés Hernández MDC, Chappell FM, Armitage PA, Makin S, Wardlaw JM

Clinical science (London, England : 1979). 2017 Dec 15;131(24):2959

Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke.

Authors: Zietemann V, Kopczak A, Müller C, Wollenweber FA, Dichgans M

Stroke. 2017 Nov;48(11):2952-2957

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Authors: Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM, Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).

Neurology. 2017 Oct 24;89(17):1829-1839

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke.

Authors: Phuah CL, Dave T, Malik R, Raffeld MR, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Jagiella JM, Hansen BM, Norrving B, Jimenez-Conde J, Roquer J, Pichler A, Enzinger C, Montaner J, Fernandez-Cadenas I, Lindgren A, Slowik A, Schmidt R, Biffi A, Rost N, Langefeld CD, Markus HS, Mitchell BD, Worrall BB, Kittner SJ, Woo D, Dichgans M, Rosand J, Anderson CD, METASTROKE., NINDS-SiGN Consortium., International Stroke Genetics Consortium.

Brain : a journal of neurology. 2017 Oct 1;140(10):2663-2672

RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke.

Authors: Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M

Circulation research. 2017 Sep 29;121(8):970-980

Waxing and waning of white matter hyperintensities.

Authors: de Leeuw FE, Nichols F 3rd

Neurology. 2017 Sep 5;89(10):984-985

White matter hyperintensity reduction and outcomes after minor stroke.

Authors: Wardlaw JM, Chappell FM, Valdés Hernández MDC, Makin SDJ, Staals J, Shuler K, Thrippleton MJ, Armitage PA, Muñoz-Maniega S, Heye AK, Sakka E, Dennis MS

Neurology. 2017 Sep 5;89(10):1003-1010

Detection, risk factors, and functional consequences of cerebral microinfarcts.

Authors: van Veluw SJ, Shih AY, Smith EE, Chen C, Schneider JA, Wardlaw JM, Greenberg SM, Biessels GJ

The Lancet. Neurology. 2017 Sep;16(9):730-740

Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity.

Authors: Valdés Hernández MDC, González-Castro V, Chappell FM, Sakka E, Makin S, Armitage PA, Nailon WH, Wardlaw JM

Frontiers in neurology. 2017;8:327

Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis.

Authors: McHutchison CA, Backhouse EV, Cvoro V, Shenkin SD, Wardlaw JM

Epidemiology (Cambridge, Mass.). 2017 Jul;28(4):608-618

Advanced Neuroimaging of Cerebral Small Vessel Disease.

Authors: Blair GW, Hernandez MV, Thrippleton MJ, Doubal FN, Wardlaw JM

Current treatment options in cardiovascular medicine. 2017 Jul;19(7):56

Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function.

Authors: Povlsen GK, Longden TA, Bonev AD, Hill-Eubanks DC, Nelson MT

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Jul;36(7):1195-201

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Authors: Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL, Rothwell PM, Rosand J, Ellinor PT, Markus HS, Traylor M, WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia.

Stroke. 2017 Jun;48(6):1451-1456

MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension.

Authors: Uiterwijk R, Staals J, Huijts M, de Leeuw PW, Kroon AA, van Oostenbrugge RJ

Journal of hypertension. 2017 Jun;35(6):1263-1270

Vascular disease and neurodegeneration: advancing together.

Authors: The Lancet Neurology

The Lancet. Neurology. 2017 May;16(5):333

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.

Authors: Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT

Nature neuroscience. 2017 May;20(5):717-726

Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms.

Authors: Joutel A, Chabriat H

Clinical science (London, England : 1979). 2017 Apr 25;131(8):635-651

Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe.

Authors: Hawkins VE, Takakura AC, Trinh A, Malheiros-Lima MR, Cleary CM, Wenker IC, Dubreuil T, Rodriguez EM, Nelson MT, Moreira TS, Mulkey DK

eLife. 2017 Apr 7;6

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Authors: Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Mar 15;37(11):2870-2877

Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis.

Authors: Backhouse EV, McHutchison CA, Cvoro V, Shenkin SD, Wardlaw JM

Neurology. 2017 Mar 7;88(10):976-984

Genetic variation at 16q24.2 is associated with small vessel stroke.

Authors: Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S, METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium., Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS, International Stroke Genetics Consortium.

Annals of neurology. 2017 Mar;81(3):383-394

Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition.

Authors: Zhang CE, Wong SM, Uiterwijk R, Staals J, Backes WH, Hoff EI, Schreuder T, Jeukens CR, Jansen JF, van Oostenbrugge RJ

Stroke. 2017 Mar;48(3):658-663

Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study.

Authors: Chappell FM, Del Carmen Valdés Hernández M, Makin SD, Shuler K, Sakka E, Dennis MS, Armitage PA, Muñoz Maniega S, Wardlaw JM

Trials. 2017 Feb 21;18(1):78

Vascular Cognitive Impairment.

Authors: Dichgans M, Leys D

Circulation research. 2017 Feb 3;120(3):573-591

Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study.

Authors: Ghaznawi R, de Bresser J, van der Graaf Y, Zwartbol MH, Witkamp TD, Geerlings MI, Hendrikse J, SMART Study Group * .

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 Jan 1;:271678X17705974

Blood pressure variability and leukoaraiosis in acute ischemic stroke.

Authors: Dickie DA, Aribisala B, Mair G, Berge E, Lindley RI, Sandercock P, von Kummer R, von Heijne A, Peeters A, Cala L, Farrall A, Morris Z, Bradey N, Potter G, Adami A, Wardlaw JM

International journal of stroke : official journal of the International Stroke Society. 2018 Jul;13(5):473-480

Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension.

Authors: Uiterwijk R, van Oostenbrugge RJ, Huijts M, De Leeuw PW, Kroon AA, Staals J

Frontiers in aging neuroscience. 2016;8:301

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.

Authors: METACOHORTS Consortium. Electronic address: joanna.wardlaw@ed.ac.uk., METACOHORTS Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2016 Dec;12(12):1235-1249

Prediction of 3-year clinical course in CADASIL.

Authors: Jouvent E, Duchesnay E, Hadj-Selem F, De Guio F, Mangin JF, Hervé D, Duering M, Ropele S, Schmidt R, Dichgans M, Chabriat H

Neurology. 2016 Oct 25;87(17):1787-1795

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

Authors: Khavandi K, Baylie RA, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD, Nelson MT, Greenstein AS

Science signaling. 2016 Oct 11;9(449):ra100

Shrinkage-mediated imaging of entire organs and organisms using uDISCO.

Authors: Pan C, Cai R, Quacquarelli FP, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A

Nature methods. 2016 Oct;13(10):859-67

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice.

Authors: Dalsgaard T, Sonkusare SK, Teuscher C, Poynter ME, Nelson MT

Scientific reports. 2016 Sep 22;6:33841

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.

Authors: Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A

eLife. 2016 Aug 1;5

Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.

Authors: Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT

The Journal of physiology. 2016 Jun 15;594(12):3271-85

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