SVDs@target

The Group

Home - SVDs@target

The SVDs@target consortium

….a consortium of excellence and complementarity

The_group

The SVDs@target consortium links major brain research centres in Europe and adds further excellence with a USA-based partner. It brings together basic scientists and academic clinicians each with a proven track record of research in SVDs and stroke and world-leading expertise in their respective fields and technologies. The consortium consists of 12 partners from from 7 countries

SVDs@target Consortium

SVDs@target consortium

Paris
INSERM
ARTTIC

Oxford
UOXF

Copenhagen
UCPH

Belgium
SAFE

Munich
LMU
TUM

Vermont
UVM

Edinburgh
UEDIN

Utrecht
UMCU

Maastricht
UM

Muenster
WWU

Tweets by SVDS@target

Tweets by SVDs_at_target

Social Media

Please follow us on Twitter: @SVDs_at_target

Please follow us on LinkedIn

Publications with PubMed ID

Blood Pressure Control and Recurrent Stroke After Intracerebral Hemorrhage in 2002 to 2018 Versus 1981 to 1986: Population-Based Study.

Authors: Li L, Zuurbier SM, Kuker W, Warlow CP, Rothwell PM

Stroke. 2021 Jul 8;:STROKEAHA121034432

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

Authors: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ

Translational psychiatry. 2021 Jul 6;11(1):376

Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study.

Authors: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun 30;:271678X211025447

Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model.

Authors: Koide M, Ferris HR, Nelson MT, Wellman GC

Frontiers in physiology. 2021;12:688468

Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study.

Authors: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ

GeroScience. 2021 Jun 23;

A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease.

Authors: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM

Frontiers in physiology. 2021;12:644837

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.

Authors: Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., Malik R, Ewers M

Nature communications. 2021 Jun 22;12(1):3825

Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage.

Authors: Wiegertjes K, Dinsmore L, Drever J, Hutchison A, Stephen J, Valdés Hernández MC, Bhatnagar P, Minks DP, Rodrigues MA, Werring DJ, de Leeuw FE, Klijn CJ, Al-Shahi Salman R, White PM, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2021 Jun 8;

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle.

Authors: Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S

Nature communications. 2021 Jun 1;12(1):3296

Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: A systematic review.

Authors: Humphreys CA, Smith C, Wardlaw JM

Neuropathology and applied neurobiology. 2021 May 26;

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort.

Authors: Hamilton O, Cox SR, Ballerini L, Bastin ME, Corley J, Gow AJ, Muñoz Maniega S, Redmond P, Valdés Hernández MDC, Wardlaw JM, Deary IJ

Neurobiology of aging. 2021 Apr 22;105:25-34

Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.

Authors: Stewart CR, Stringer MS, Shi Y, Thrippleton MJ, Wardlaw JM

Frontiers in neurology. 2021;12:647848

Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study.

Authors: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M

Translational psychiatry. 2021 May 17;11(1):291

Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI.

Authors: Arts T, Meijs TA, Grotenhuis H, Voskuil M, Siero J, Biessels GJ, Zwanenburg J

Frontiers in neuroscience. 2021;15:665480

Fluid Transport in the Brain.

Authors: Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews. 2021 May 5;

Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI.

Authors: Sloots JJ, Biessels GJ, de Luca A, Zwanenburg JJM

NeuroImage. 2021 Aug 1;236:118078

Improving Clinical Detection of Acute Lacunar Stroke: Analysis From the IST-3.

Authors: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM, Third International Stroke Trial Collaborators.

Stroke. 2020 May;51(5):1411-1418

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases.

Authors: Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U, Chappell FM, Brown R, Jaime Garcia D, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés-Hernández MC, Doubal FN, Wardlaw JM

Stroke. 2020 May;51(5):1503-1506

PIP<sub>2</sub> corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.

Authors: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 27;118(17)

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses.

Authors: Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D

Hypertension (Dallas, Tex. : 1979). 2021 Jun;77(6):2004-2013

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3.

Authors: Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM

European stroke journal. 2021 Mar;6(1):81-88

Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities.

Authors: Kerkhofs D, Wong SM, Zhang E, Staals J, Jansen JFA, van Oostenbrugge RJ, Backes WH

Neurology. 2021 Apr 27;96(17):e2192-e2200

Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.

Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

Frontiers in physiology. 2021;12:643468

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke.

Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

Frontiers in neurology. 2021;12:634460

Body Mass Index and Arterial Stiffness Are Associated With Greater Beat-to-Beat Blood Pressure Variability After Transient Ischemic Attack or Minor Stroke.

Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Stroke. 2021 Apr;52(4):1330-1338

Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.

Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

Stroke. 2021 Mar;52(3):931-936

Direct Measurement of Cerebrospinal Fluid Production in Mice.

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

A Case of Sporadic Cerebral Small Vessel Disease in an Identical Twin.

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus.

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2021 Feb;30(2):285-298

Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management.

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

Cerebral Amyloid Angiopathy: Still a Syndromal Diagnosis.

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Apr;17(4):665-685

Age and sex distribution of beat-to-beat blood pressure variability after transient ischemic attack and minor stroke: A population-based study.

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2020 Nov 9;:1747493020971905

Physiological determinants of residual cerebral arterial pulsatility on best medical treatment after TIA or minor stroke.

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun;41(6):1463-1471

Clinical management of cerebral small vessel disease: a call for a holistic approach.

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;134(2):127-142

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

Vascular control of the CO<sub>2</sub>/H<sup>+</sup>-dependent drive to breathe.

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease.

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity.

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

Circadian control of brain glymphatic and lymphatic fluid flow.

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke.

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis.

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes.

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

The Brain's Glymphatic System: Current Controversies.

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

Intracranial hemodynamic relationships in patients with cerebral small vessel disease.

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage.

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

Aquaporin 1 and the Na<sup>+</sup>/K<sup>+</sup>/2Cl<sup>-</sup> cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI.

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819