INVESTIGATE-SVDs

Imaging NeuroVascular, Endothelial and STructural Integrity
in prepAration to TrEat Small Vessel Diseases



Participating Centres:

Edinburgh (coordinating centre)

Neuroimaging Sciences and Brain Research Imaging Centre, University of Edinburgh Crewe Rd, Edinburgh, United Kingdom.
Coordinating Investigator: Prof. Joanna Wardlaw.

LMU Munich

Institute for Stroke and Dementia Research. Klinikum der Universität München. Feodor-Lynen-Straße 17, Munich, Germany.
Prof. Dr. Martin Dichgans

Maastricht

Department of Neurology, University Medical Center Maastricht, University of Maastricht. P. Debyelaan 25, Maastricht, The Netherlands.
Prof. Dr. Robert van Oostenbrugge

General Information


Type of study: international observational study
Duration: 8 days, follow-up after 1 year on the phone or by mail
Participants: 75 patients
Main Inclusion Criteria: Clinical features of small vessel disease, age > 18 years, no contraindications to MRI
Status: recruitment completed in the UK and in Germany, recruitment ongoing in the Netherlands.

Background and Aims


Damage to the small blood vessels in the brain (known as „Small Vessel Disease“) can lead to stroke and vascular dementia.

Changes in the way that the brain‘s smallest blood vessels work appears to be important in causing small vessel disease to develop. Until recently this has been very difficult to study in humans. Now we plan to use newly developed advanced MRI brain scans to measure how well the small blood vessels are working to prevent leakage of damaging inflammatory cells into the brain tissue and ensure enough blood gets to the brain when its needed.

INVESTIGATE-SVDs is a multicentre, non-commercial observational study which will be performed in 3 different countries in Europe (UK, Germany, the Netherlands).
The study will be performed over 2 years and recruit 75 participants.

By participating in this study you will make an important contribution to the research on cerebral small vessel diseases.



We thank you for your interest,

Prof. Joanna Wardlaw, MD
Coordinating Investigator

Magnetic resonance imaging (MRI)

Magnetic resonance imaging is a neuroimaging technique based on magnetic fields. The investigation is not dangerous and is not linked with radiation exposure. Noisy knocking sounds occur during the recording; you will wear earplugs during the scan. For a short time you will breath CO2 to investigate the function of the small vessels in the brain (only once during 7-Tesla MRI).



Your Advantages:
 
  • Stable medical assitance
  • No waiting period
  • Study nurse as direct contact
  • High resolution MRI
  • Blood analysis
  • Blod pressure monitoring with a premium blood pressure devide
  • Comprehensive medical attendance

Study flow

Visit 1:


  • Face-to-face interview
  • Physical examination
  • Blood drawing
  • Neuropsychological tests
  • Instructions for how to use blood pressure measuring device

 

Visit 2:


After 7 days
  • MRI scan
  • Return of blood pressure measuring device

Follow up:


After 1 year
  • On the phone or by mail
  • Interview (Medical history)
  • Shortened Neuropsychological tests
  • Duration: ca. 40 min

  

Search
Home
Menu
Top

Tweets by SVDS@target

Publications with PubMed ID

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 May 20;

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Salman RA, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280