Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases
Edinburgh (coordinating centre)Neuroimaging Sciences and Brain Research Imaging Centre, University of Edinburgh Crewe Rd, Edinburgh, United Kingdom.
Coordinating Investigator: Prof. Joanna Wardlaw.
LMU MunichInstitute for Stroke and Dementia Research. Klinikum der Universität München. Feodor-Lynen-Straße 17, Munich, Germany.
Prof. Dr. Martin Dichgans
MaastrichtDepartment of Neurology, University Medical Center Maastricht, University of Maastricht. P. Debyelaan 25, Maastricht, The Netherlands.
Prof. Dr. Robert van Oostenbrugge
Type of study: international observational study
Duration: 8 days, follow-up after 1 year on the phone or by mail
Participants: 75 patients
Main Inclusion Criteria: Clinical features of small vessel disease, age > 18 years, no contraindications to MRI
Status: recruitment completed in the UK and in Germany, recruitment ongoing in the Netherlands.
Background and Aims
Damage to the small blood vessels in the brain (known as „Small Vessel Disease“) can lead to stroke and vascular dementia.
Changes in the way that the brain‘s smallest blood vessels work appears to be important in causing small vessel disease to develop. Until recently this has been very difficult to study in humans. Now we plan to use newly developed advanced MRI brain scans to measure how well the small blood vessels are working to prevent leakage of damaging inflammatory cells into the brain tissue and ensure enough blood gets to the brain when its needed.
INVESTIGATE-SVDs is a multicentre, non-commercial observational study which will be performed in 3 different countries in Europe (UK, Germany, the Netherlands).
The study will be performed over 2 years and recruit 75 participants.
By participating in this study you will make an important contribution to the research on cerebral small vessel diseases.
We thank you for your interest,
Prof. Joanna Wardlaw, MD
Magnetic resonance imaging (MRI)
Magnetic resonance imaging is a neuroimaging technique based on magnetic fields. The investigation is not dangerous and is not linked with radiation exposure. Noisy knocking sounds occur during the recording; you will wear earplugs during the scan. For a short time you will breath CO2 to investigate the function of the small vessels in the brain (only once during 7-Tesla MRI).
- Stable medical assitance
- No waiting period
- Study nurse as direct contact
- High resolution MRI
- Blood analysis
- Blod pressure monitoring with a premium blood pressure devide
- Comprehensive medical attendance
- Face-to-face interview
- Physical examination
- Blood drawing
- Neuropsychological tests
- Instructions for how to use blood pressure measuring device
After 7 days
- MRI scan
- Return of blood pressure measuring device
After 1 year
- On the phone or by mail
- Interview (Medical history)
- Shortened Neuropsychological tests
- Duration: ca. 40 min