Utrecht University (UU) and University Medical Center Utrecht (UMCU)

University Medical Center Utrecht
With almost 30,000 students, over 6,000 staff, and an annual budget of 765 million euros (2014), Utrecht University is one of the largest general research universities in Europe. It ranks first in the Netherlands and 16th in Europe on the 2014 Shanghai Ranking. In 2013, it generated 234 million Euro in external research funding.

 

The University Medical Centre Utrecht (UMCU) is one of the largest public health care institutions in the Netherlands, with over 11,000 employees, including almost 1000 PhD students. The department of Neurology & Neurosurgery at UMCU treats over 600 patients with acute stroke each year and has a dedicated vascular cognitive impairment clinic. The Center for Image Sciences (CIS) is performing world leading imaging research and image based therapy research at the UMCU. The Center for Image Sciences (CIS) at the UMCU employs and trains 120 PhD students in grant funded research projects. The MRI physics group is one of the largest in Europe with major developments in the field of 7T MRI of the brain.

 

 

Key staff

Geert Jan Biessels
Prof. Geert Jan Biessels is professor of neurology at the UMC Brain Center of the University Medical Centre Utrecht, the Netherlands. His major research interest is vascular cognitive impairment (VCI), with a particular focus on novel imaging markers and the role of diabetes.

Using the unique properties of high field 7T-MRI his group managed to detect cerebral microinfarcts in vivo. The technique has now been translated to 3T-MRI. A next goal is to non-invasively image structure and function of the small vessels themselves, thus getting closer to the core disease processes. This is pursued in Zoom@SVDs as part of the SVDs@target program. He is PI of the Dutch Heart-Brain connection program (www.heart-brain.nl/), the Meta VCI Map consortium (www.metavcimap.org), and two large multicentre RCTs on prevention of cognitive decline in patients with in type 2 diabetes (PMID: 29334906). In 2015 he received the senior investigator award of the European Stroke Organisation (ESO). He authored over 300 research papers.

SVD@target team at UMCU

Jereon Hendrikse

Prof. Jeroen Hendrikse (1976) is professor of neuroradiology at the radiology department (Imaging Division) of the University Medical Center Utrecht, The Netherlands. His major research interest is novel imaging markers to quantify cerebrovascular diseases. His three major research lines can be distinguished as the ‘3Ps’: the investigation of the brain Pipes (vasculature), Perfusion and Parenchyma. With 3T-MRI and 7T-MRI his group visualized and quantified cerebral perfusion and cerebrovascular reserve with arterial spin labeling (ASL) MRI and the burden of intracranial atherosclerosis and plaques with intracranial vessel wall MRI. The innovative and non-invasive methods developed within this research lines are translated to daily clinical practice including other patient groups such as patients with brain tumors. He is the first radiologists awarded with an ERC starting grant (HEARTOFSTROKE) with the goal to unravel the causes of cerebral infarcts in individual patients by investigating in detail ‘Pipes, Perfusion and Parenchyma’. Furthermore, he was awarded with major Dutch national research grants (VENI, VIDI, STW, Dutch Heart Association). He is chair of the Dutch radiologists continuing medical education (CME) program. He authored 140 research papers and wrote an educational book for the general public (‘This is our brain’).

 

Jaco Zwanenburg

Dr. Jaco Zwanenburg is associate professor of advanced MRI at the department of Radiology (Imaging Division) of the University Medical Center Utrecht, The Netherlands. His research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients. He was awarded an ERC starting grant (SmallVesselMRI) for developing new techniques for imaging the microvascular function, including the pulsatile motion induced by the small vessels, which drive the waste transport in the brain.

 

Dr. ir. Jeroen Siero is assistant professor of advanced MRI at the department of Radiology (Imaging Division) of the University Medical Center of Utrecht and at the Spinoza Centre for Neuroimaging Amsterdam, The Netherlands. His main research focus is on hemodynamic MRI techniques from hardware development to image analysis of high fidelity hemodynamic MRI data. A particular interest is neurovascular coupling in healthy and diseased brain and the separation of vascular and neuronal sources to BOLD fMRI signals using respiratory challenges. A physiological parameter with great potential for investigating the health of the brain’s vasculature is cerebrovascular reactivity (CVR). CVR is the vasodilatory response of cerebral vessels under hemodynamic stress conditions. Examining fine-scale CVR is of particular importance as it is hypothesized that disturbed capillary blood flow patterns play a crucial role in the events preceding tissue ischemia, small vessel disease and dementia. Using state-of-the art methods, I intend to produce CVR maps with superior spatiotemporal detail compared to existing techniques. Ultimately, these maps would identify tissue at risk, and will guide selection of patients for tailored treatment protocols.
Tine Arts

Tine Arts is a PhD student at the department of radiology. She has a background in physics and is keen of MRI research due to its physical fundamentals and medical applications. Her research interest is in the applied MRI sciences, but she is also involved in the development of methods for MRI data analysis.

 

Laurien Onkenhout

Laurien Onkenhout is a Ph.D. student at the Brain Center Rudolf Magnus of the University Medical Centre Utrecht. She has a particular interest in vascular and cognitive neurology. She completed her medical degree at the Rijksuniversiteit Groningen. Before commencing her last year at the University she did some traveling which included volunteer work in Nepal and two extracurricular internship/observership, one in India and one at Harvard Medical school. She is now very much looking forward to working on the SVDs@target. In the SVDs@target project she will primarily be working on the ZOOM@SVDs and TREAT-SVDs work packages.

 

Hilde van den Brink is a PhD student at the University Medical Centre Utrecht, the Netherlands, in the research group of Professor Geert Jan Biessels. She graduated at Utrecht University in both Neuropsychology and Neuroscience. During her master studies she specialized in in vivo cerebral microinfarcts in the group of Professor Geert Jan Biessels and in a fellowship with Dr. Eric Smith, University of Calgary, Canada. In her PhD, Hilde uses 7Tesla MRI to better understand the mechanisms that drive small vessel disease-related brain damage and cognitive problems. This is done in Zoom@SVDs as part of the SVDs@target program, where she is involved in patient recruitment, patient visits/scanning, and data analyses.
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Publications with PubMed ID

Authors: Li L, Zuurbier SM, Kuker W, Warlow CP, Rothwell PM

Stroke. 2021 Jul 8;:STROKEAHA121034432

PMID: 34233466

Authors: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ

Translational psychiatry. 2021 Jul 6;11(1):376

PMID: 34226517    Open Access: PMC8257729

Authors: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun 30;:271678X211025447

PMID: 34187229

Authors: Koide M, Ferris HR, Nelson MT, Wellman GC

Frontiers in physiology. 2021;12:688468

PMID: 34168571    Open Access: PMC8218876

Authors: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ

GeroScience. 2021 Jun 23;

PMID: 34160780

Authors: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM

Frontiers in physiology. 2021;12:644837

PMID: 34149442    Open Access: PMC8207286

Authors: Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., Malik R, Ewers M

Nature communications. 2021 Jun 22;12(1):3825

PMID: 34158479    Open Access: PMC8219708

Authors: Wiegertjes K, Dinsmore L, Drever J, Hutchison A, Stephen J, Valdés Hernández MC, Bhatnagar P, Minks DP, Rodrigues MA, Werring DJ, de Leeuw FE, Klijn CJ, Al-Shahi Salman R, White PM, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2021 Jun 8;

PMID: 34103345

Authors: Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S

Nature communications. 2021 Jun 1;12(1):3296

PMID: 34075043    Open Access: PMC8169932

Authors: Humphreys CA, Smith C, Wardlaw JM

Neuropathology and applied neurobiology. 2021 May 26;

PMID: 34037264

Authors: Hamilton O, Cox SR, Ballerini L, Bastin ME, Corley J, Gow AJ, Muñoz Maniega S, Redmond P, Valdés Hernández MDC, Wardlaw JM, Deary IJ

Neurobiology of aging. 2021 Apr 22;105:25-34

PMID: 34022536

Authors: Stewart CR, Stringer MS, Shi Y, Thrippleton MJ, Wardlaw JM

Frontiers in neurology. 2021;12:647848

PMID: 34017302    Open Access: PMC8129542

Authors: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M

Translational psychiatry. 2021 May 17;11(1):291

PMID: 34001857    Open Access: PMC8129147

Authors: Arts T, Meijs TA, Grotenhuis H, Voskuil M, Siero J, Biessels GJ, Zwanenburg J

Frontiers in neuroscience. 2021;15:665480

PMID: 33981198    Open Access: PMC8107291

Authors: Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews. 2021 May 5;

PMID: 33949874

Authors: Sloots JJ, Biessels GJ, de Luca A, Zwanenburg JJM

NeuroImage. 2021 Aug 1;236:118078

PMID: 33878376

Authors: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM, Third International Stroke Trial Collaborators.

Stroke. 2020 May;51(5):1411-1418

PMID: 32268853    Open Access: PMC7185055

Authors: Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U, Chappell FM, Brown R, Jaime Garcia D, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés-Hernández MC, Doubal FN, Wardlaw JM

Stroke. 2020 May;51(5):1503-1506

PMID: 32264759    Open Access: PMC7185057

Authors: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 27;118(17)

PMID: 33875602    Open Access: PMC8092380

Authors: Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D

Hypertension (Dallas, Tex. : 1979). 2021 Jun;77(6):2004-2013

PMID: 33813844    Open Access: PMC8115430

Authors: Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM

European stroke journal. 2021 Mar;6(1):81-88

PMID: 33817338    Open Access: PMC7995323

Authors: Kerkhofs D, Wong SM, Zhang E, Staals J, Jansen JFA, van Oostenbrugge RJ, Backes WH

Neurology. 2021 Apr 27;96(17):e2192-e2200

PMID: 33762423    Open Access: PMC8166427

Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

Frontiers in physiology. 2021;12:643468

PMID: 33716793    Open Access: PMC7947694

Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

Frontiers in neurology. 2021;12:634460

PMID: 33732208    Open Access: PMC7956970

Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Stroke. 2021 Apr;52(4):1330-1338

PMID: 33588593    Open Access: PMC7610951

Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

Stroke. 2021 Mar;52(3):931-936

PMID: 33535786    Open Access: PMC7903981

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

PMID: 33357428    Open Access: PMC8186543

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

PMID: 33362520    Open Access: PMC7747080

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2021 Feb;30(2):285-298

PMID: 33307988    Open Access: PMC7854491

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

PMID: 33249860    Open Access: PMC7720874

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

PMID: 33148147

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Apr;17(4):665-685

PMID: 33185327

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2020 Nov 9;:1747493020971905

PMID: 33167788

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun;41(6):1463-1471

PMID: 33153374    Open Access: PMC8138338

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;134(2):127-142

PMID: 33118960    Open Access: PMC7817338

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

PMID: 32999319    Open Access: PMC7528110

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

PMID: 32924935    Open Access: PMC7521922

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

PMID: 32936435    Open Access: PMC7803876

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

PMID: 32764198    Open Access: PMC7116588

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641    Open Access: PMC7660704

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524    Open Access: PMC7375109

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280