Institut national de la santé et de la recherche médicale (INSERM)

Inserm
Inserm is the leading scientific and technological academic institute in France devoted to biomedical research and public health, with approximately 320 departments and 6000 researchers. Inserm, which holds a portfolio of 1279 patent families (with > 25% licensed patents), ranks 1st among European academic institutions in patent filling for biomedical research.
The Department of Genetics and Pathogenesis of Cerebrovascular Diseases is part of Inserm. The department is committed to advance diagnosis, research and treatment options in inherited diseases affecting the brain vessels. One major focus of our research is on pathogenic mechanisms of monogenic form of cerebral SVDs. Our methodological expertise is in molecular, proteomic, structural and functional analysis of brain microvessels in genetically engineered mouse models using ex vivo and in vivo approaches. The department has a longstanding interest in CADASIL, the most frequent inherited SVD caused by dominant mutations in the NOTCH3 receptor, and has produced some of the seminal work in this field.

Roles and tasks of INSERM in SVDs@target

Inserm will lead WP3 (Microvascular matrisome and vascular integrity). In this WP, Inserm will identify changes in the extracellular matrix of brain microvessels in SVDs, shared by multiple SVDs as well as changes specific for individual SVDs and will determine whether and how these changes contribute to microvessel dysfunction and brain lesions.  Inserm will also contribute to WP2 (analysis of blood brain barrier integrity in mouse models of monogenic forms of SVD), WP4 (proteomic analysis of vascular basement membranes), and WP5 (genetic manipulation of selected targets in the mouse for validation through interventions and in vivo analysis of cerebrovascular function).

 

 

 

Key staff

Prof. Anne Joutel

Research Director

 

Major field of research: SVDs; specific expertise in genetics, mouse models of SVDs, biochemistry, proteomics, electron microscopy and cerebrovascular physiology

 

Prof. Joutel has a longstanding interest in monogenic forms of SVDs and has produced seminal work on CADASIL and cerebrovascular function of Notch3 receptor. Her lab originally identified the Notch3 gene and delineated its role in CADASIL (Joutel et al. Nature 1995; Joutel et al. Lancet 1997). Her lab has developed and characterized multiple Notch3-related mouse models, including the first (and only) mouse model recapitulating most of the key features of CADASIL, as well as conditional and inducible mouse models of activation and inactivation of Notch in SMCs. She has initiated with Prof. Nelson (University of Vermont) a transatlantic research network on the pathogenesis of SVDs funded by the Fondation Leducq (website).

 

Prof. Joutel is a work package leader (WP3) in SVDs@target.

 

SVD@target team at INSERM

Dr. Monara Angelim
Senior Post-Doc


I am a Postdoc in Joutel's team, at IPNP (Paris). After my PhD in Neuroscience, I joined the research group to collaborate in CADASIL project. Our aiming is better characterize the accumulation of Notch3ECD receptor in the brain vessels of CADASIL mouse models. For that, techniques of immunohistofluorescence, electronmicroscopy, confocal/AiryScan imaging and cell  quantification have been used.




Dr. Julien Ratelade
Senior Post-Doc


Dr. Hussein Kalakech
Junior Post-Doc


Mrs. Valerié Domenga
Engineer
Search
Home
Menu
Top

Tweets by SVDS@target

Publications with PubMed ID

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Mar 18;

PMID: 32183562

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280