University of Oxford (UOXF)

University of Oxford
University of Oxford has been one of the world’s most influential universities for eight centuries, renowned for both its research and teaching. Oxford has more world-leading academics (rated 4* in the UK Government’s 2014 Research Effectiveness Framework Exercise) and a higher research income (£600 million in 2014) than any other UK university. Of the University’s four academic divisions, Medical Sciences accounts for over 60% of external research income. The Division is internationally recognised for its research and is one of the largest biomedical research centres in Europe, with over 2,500 researchers and 2,800 students across 5 non-clinical and 12 clinical departments, which includes the Nuffield Department of Clinical Neurosciences (NDCN).The Centre for Prevention of Stroke and Dementia (CPSD) is one of the five divisions of NDCN. Its aims are to do research that increases understanding of the causes of cerebrovascular disease and improve the prevention of stroke and vascular dementia in routine clinical practice. The centre was founded as the Stroke Prevention Research Unit (SPRU) in 2000 by Professor Peter Rothwell with initial funding from the MRC and the Stroke Association. Now comprising about 40 researchers and support staff, the centre is regarded as one of the most productive stroke research groups in the world.Our main areas of current research include:

  • Pathology, prognosis and treatment of carotid stenosis
  • Understanding of the link between blood pressure and risks of stroke and dementia
  • Improve secondary prevention of stroke after a TIA (transient ischaemic attack) or minor stroke
  • Improving phenotyping and prevention of stroke by more effective brain and vascular imaging
  • Biomarkers and genetics of ischaemic stroke and vascular cognitive impairment
  • Reliable determination of the effects of treatments, including randomized trials, systematic reviews, developing methods to better target treatments at individuals and alternatives to randomised trials.
Our research has led to major changes in clinical practice and clinical guidelines on multiple aspects of primary and secondary prevention of stroke, including:

  1. Prevention of stroke in patients with recently symptomatic carotid stenosis
  2. Urgency of assessment and investigation of patients with TIA and minor stroke
  3. Effective secondary prevention after TIA and minor stroke
  4. Diagnosis and treatment of hypertension in prevention of stroke

Roles and tasks of UOXF in SVDs@target

CPSD has a particular interest in hypertension and stroke and the effect of BPv on cerebral perfusion and end-organ damage. CPSD will lead the clinical section of WP1 and will contribute to WP 5 (Interventions).



Key staff

Prof. Peter Rothwell

Action Research Professor of Neurology (Oxford), endowed chair;
Director of the Stroke Prevention Research Unit (Oxford);
Director of the Stroke and Dementia Theme of the Oxford Biomedical Research Centre;
Executive committee member of the European Stroke Organisation (ESO);


Major field of research: stroke and dementia; hypertension; specific expertise in: epidemiology, clinical research, BP measurement and monitoring.


Prof. Rothwell has extensive experience in international and national collaborative projects and has been the lead investigator in multiple large-scale clinical studies. He also has long-standing expertise in randomised controlled trials in prevention of stroke.


SVD@target team at UOXF

Dr. Shane Lyons

Research Fellow


Dr. Alastair Webb

Research Fellow

Clinician Scientist with experience of analysis and interpretation of BP monitoring data and vascular physiology studies.



Tweets by SVDS@target

Publications with PubMed ID

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2020 Sep 16;

PMID: 32936435

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2020 Sep 15;

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Aug 7;

PMID: 32764198

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Salman RA, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524    Open Access: PMC7375109

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280