- Pathology, prognosis and treatment of carotid stenosis
- Understanding of the link between blood pressure and risks of stroke and dementia
- Improve secondary prevention of stroke after a TIA (transient ischaemic attack) or minor stroke
- Improving phenotyping and prevention of stroke by more effective brain and vascular imaging
- Biomarkers and genetics of ischaemic stroke and vascular cognitive impairment
- Reliable determination of the effects of treatments, including randomized trials, systematic reviews, developing methods to better target treatments at individuals and alternatives to randomised trials.
Our research has led to major changes in clinical practice and clinical guidelines on multiple aspects of primary and secondary prevention of stroke, including:
- Prevention of stroke in patients with recently symptomatic carotid stenosis
- Urgency of assessment and investigation of patients with TIA and minor stroke
- Effective secondary prevention after TIA and minor stroke
- Diagnosis and treatment of hypertension in prevention of stroke
CPSD has a particular interest in hypertension and stroke and the effect of BPv on cerebral perfusion and end-organ damage. CPSD will lead the clinical section of WP1 and will contribute to WP 5 (Interventions).
Prof. Peter Rothwell
Action Research Professor of Neurology (Oxford), endowed chair;
Director of the Stroke Prevention Research Unit (Oxford);
Director of the Stroke and Dementia Theme of the Oxford Biomedical Research Centre;
Executive committee member of the European Stroke Organisation (ESO);
Major field of research: stroke and dementia; hypertension; specific expertise in: epidemiology, clinical research, BP measurement and monitoring.
Prof. Rothwell has extensive experience in international and national collaborative projects and has been the lead investigator in multiple large-scale clinical studies. He also has long-standing expertise in randomised controlled trials in prevention of stroke.
Dr. Shane Lyons
Dr. Alastair Webb
Research FellowClinician Scientist with experience of analysis and interpretation of BP monitoring data and vascular physiology studies.