University of Münster (WWU)

University of Münster
The Westfaelische Wilhelms-Universitaet (WWU), Muenster, Germany, is the fourth largest university in Germany and is internationally recognised for its research focus on ECM, vascular biology, inflammation and both optical and medical imaging. This is reflected in several German Research Foundation funded collaborative research centres (CRCs/SFBs) in biomedicine, including Multiple Sclerosis (SFB TR 128), Immune Barriers (SFB 1009), Cell Dynamics (SFB 629), Molecular Imaging (SFB 656) and the Cluster of Excellence, Cells-in-Motion (CiM), of which Partner 8 is the spokesperson. The group of partner has contributed significantly to the structural and functional characterization cerebral blood vessels and mechanisms of immune cell migration into the brain.

Roles and tasks of WWU in SVDs@target

WWU will lead WP4 (Inflammatory mechanisms: immune cell binding and transmigration in SVDs) and will contribute to WP2 (Blood brain barrier integrity and perivascular flow), WP3 (Microvascular matrisome and vascular integrity) and WP5 (Validation of mechanisms through interventions).

 

 

Key staff

Prof. Lydia Sorokin
Prof. Lydia Sorokin

Full Professor and Director of Physiological Chemistry and Pathobiochemisty (W3), Münster University, Münster, Germany;
Spokesperson of the Cells-in-Motion Cluster of Excellence, University of Münster;
Member of the North Rhein-Westphalian Academy of Sciences, Humanities & Arts;
External Advisory Board member of the University of Cologne, Center for Molecular Medicine (ZMMK);
Scientific Steering Committee member of CRC Transregio 128 - Multiple Sclerosis;
Chair of the external advisory Board,  Max-Planck Institute for Medical Research, Heidelberg, Germany.
External Advisory Board, Interdisciplinary Centre for Clinical Research (IZKF), University of Erlangen-Nürnberg, Germany.
Elected Member, DFG panel ‘Basic Principles of Biology and Medicine’

Prof. Sorokin is a work package leader (WP4) in SVDs@target.



SVD@target team at WWU

Dr. Tushar Deshpande

Dr. Tushar Deshpande is a non-clinical pharmacologist by training with a broad interest in various neuropathologies and therapeutic strategies thereof. He is investigating the role of inflammation and innate immune system in the pathophysiology of cerebral small vessel diseases.

 

Dr. Jula Huppert

Postdoctoral scientist

Immunologist with experience in ischemic stroke models and confocal microscopy of brain slices.

 

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Tweets by SVDS@target

Publications with PubMed ID

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

PMID: 33357428

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

PMID: 33362520    Open Access: PMC7747080

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2020 Dec 13;:961203320979045

PMID: 33307988

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

PMID: 33249860    Open Access: PMC7720874

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

PMID: 33148147

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Nov 13;

PMID: 33185327

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2020 Nov 9;:1747493020971905

PMID: 33167788

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020 Nov 5;:271678X20969984

PMID: 33153374

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;

PMID: 33118960

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

PMID: 32999319    Open Access: PMC7528110

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

PMID: 32924935    Open Access: PMC7521922

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

PMID: 32936435

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

PMID: 32764198

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641    Open Access: PMC7660704

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524    Open Access: PMC7375109

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280