University of Münster (WWU)

University of Münster
The Westfaelische Wilhelms-Universitaet (WWU), Muenster, Germany, is the fourth largest university in Germany and is internationally recognised for its research focus on ECM, vascular biology, inflammation and both optical and medical imaging. This is reflected in several German Research Foundation funded collaborative research centres (CRCs/SFBs) in biomedicine, including Multiple Sclerosis (SFB TR 128), Immune Barriers (SFB 1009), Cell Dynamics (SFB 629), Molecular Imaging (SFB 656) and the Cluster of Excellence, Cells-in-Motion (CiM), of which Partner 8 is the spokesperson. The group of partner has contributed significantly to the structural and functional characterization cerebral blood vessels and mechanisms of immune cell migration into the brain.

Roles and tasks of WWU in SVDs@target

WWU will lead WP4 (Inflammatory mechanisms: immune cell binding and transmigration in SVDs) and will contribute to WP2 (Blood brain barrier integrity and perivascular flow), WP3 (Microvascular matrisome and vascular integrity) and WP5 (Validation of mechanisms through interventions).

 

 

Key staff

Prof. Lydia Sorokin
Prof. Lydia Sorokin

Full Professor and Director of Physiological Chemistry and Pathobiochemisty (W3), Münster University, Münster, Germany;
Spokesperson of the Cells-in-Motion Cluster of Excellence, University of Münster;
Member of the North Rhein-Westphalian Academy of Sciences, Humanities & Arts;
External Advisory Board member of the University of Cologne, Center for Molecular Medicine (ZMMK);
Scientific Steering Committee member of CRC Transregio 128 - Multiple Sclerosis;
Chair of the external advisory Board,  Max-Planck Institute for Medical Research, Heidelberg, Germany.
External Advisory Board, Interdisciplinary Centre for Clinical Research (IZKF), University of Erlangen-Nürnberg, Germany.
Elected Member, DFG panel ‘Basic Principles of Biology and Medicine’

Prof. Sorokin is a work package leader (WP4) in SVDs@target.



SVD@target team at WWU

Dr. Tushar Deshpande

Dr. Tushar Deshpande is a non-clinical pharmacologist by training with a broad interest in various neuropathologies and therapeutic strategies thereof. He is investigating the role of inflammation and innate immune system in the pathophysiology of cerebral small vessel diseases.

 

Dr. Jula Huppert

Postdoctoral scientist

Immunologist with experience in ischemic stroke models and confocal microscopy of brain slices.

 

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Tweets by SVDS@target

Publications with PubMed ID

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2020 Sep 16;

PMID: 32936435

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2020 Sep 15;

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Aug 7;

PMID: 32764198

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Salman RA, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524    Open Access: PMC7375109

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280