News, Press Releases and Articles

For the Final General Assembly Meeting, the Coordinator Martin Dichgans from LMU welcomed the SVDs@target consortium to Munich, Germany. We are very happy to have been able to finally meet in person again before the SVDs@target project ends on 31st December 2021.

Please read the full article here

The INVESTIGATE-SVDs study is one of our three multicentre clinical studies, which Edinburgh (UEDIN), Maastricht (UM) and Munich (LMU) conducted. The study asses the relationships of Blood-Brain-Barrier (BBB) integrity, cerebrovascular reactivity MRI, pulsatility and Cerebrospinal Fluid Flow (CSF) in sporadic SVD and CADASIL patient. The study aims to establish associations between these measures of vascular function, risk factors like blood pressure and its variability (regular measurements over seven days), and brain parenchymal lesions. In total 75 patient have been recruited – 45 sporadic SVDs and 30 CADASIL patients. As the first clinical study that completed recruitment within this project, it also succeeded the feasibility of complex multisite MRI.

Now the study protocol was published and it underlines the good collaboration between the clinical sites and the great effort of all team members to make this study a success. Congrats to the entire team.

The publication about the study protocol can be read here.

If you want to read more information about the INVESTIGATE-SVDs study, please click here.
Hilde hands over flowers to the final ZOOM@SVDs participant

With the inclusion of the last patient in the ZOOM@SVDs clinical study, the SVDs@target project can account another great achievement and a big step forward. The team around Prof. Gert Jan Biessels and PhD-candidate Hilde van den Brink can now start to analyse the enormous amount of data, which they collected from 103 sporadic Small Vessel Disease patients and controls. The baseline assessments will also be compared to a cohort of CADASIL patients and controls, which were recruited from project partner LMU. We are very excited about the insight this new data will give and we want to thank everybody involved in the ZOOM@SVDs study for their continous effort and great work but our very special "Thanks" goes to all patients for their trust in this clinical study.

The ZOOM@SVDs study is one of our three multicentre clinical studies, conducted by Utrecht (UMCU) and Munich (LMU). It is a observational cohort study with two years follow-up and aims to establish measures of cerebral small vessel dysfunction on 7T MRI as novel disease markers of SVD. ZOOM@SVDs recruited 20 CADASIL patients, 60 sporadic patients and respective controls. The participants undergo 7T brain MRI to assess different aspects of small vessel function including small vessel reactivity, cerebral perforating artery flow, and pulsatility, further it includes clinical and neuropsychological assessment as well as 3T brain MRI to assess conventional SVD imaging markers.

The study protocol was now published and will help the scientific community to plan and conduct future trials on SVDs. In addition, the successful ZOOM@SVDs study shows the good collaboration between Utrecht and Munich. Congrats to this achievement to both teams.

The publication about the study protocol can be read here.

If you want to read more information about the ZOOM@SVDs study, please click here.

SVDs@target partner SAFE (Stroke Alliance for Europe) prepared a very special campaign for the European Stroke Awareness Day on 11th March 2021. Three SVDs@target trial participants in the UK were interviews with the aim of gathering the patient perspective of participation in a clinical trial especially during a pandemic. SAFE asked them about their motivations of participation, the benefits and whether they would encourage others to get involved in clinical trial .Such interviews and its dissemination are very important to bring researchers and patients closer together, it helps patients to raise their voice, reduces fears and is encouraging for other patients to participate in such clinical trials.

Thank you SAFE for your very important work in our SVDs@target project and for all SVDs affected patients and their families.

If you want to read the full interviews please follow this link.

Prof. Mark Nelson, University of Vermont PI and also the person in-charge for SVDs@target project at UVM was interviewed by National Academy of Sciences to accompany inaugural an article from his research group in SVDs@target project.

Read his interview here and article here

For the 5th General Assembly we planned a meeting in Utrecht. Unfortunately, a pandemic got in the way and we had to cancel the physical meeting and instead we organized a virtual one. Nevertheless, it was nice seeing each other again and discussing intensively about Small Vessel Diseases.

Please read the full article here

To the question "Why do you do it" Michael Stringer from UEDIN answered "My research focuses on applying advanced imaging and mathematical methods to study disease. I enjoy applying these tools to study real world problems, and as a highly multidisciplinary area it provides a lot of variety – it is seldom dull."

Please read the full "Meet the SVDs@traget Investigator" interview with Michael Stringer here

"SVDs@target project will give us more insight in the mechanisms underlying the pathogenesis of cSVD. The acquired knowledge will hopefully make the next step possible were we can investigate more specific treatments that can reduce progression of the disease. Further this new knowledge can also provide us new chances for earlier detection of the disease." says Danielle Kerkhofs, researcher at University of Maastricht and member of the SVDs@target consortium.

Please read the full interview here.

In the course of the International Stroke Conference, which is organized anually by the American Heart Association, our partner Prof. Maiken Nedergaard was awarded with this year's "Thomas Willis Lecture". The award recognizes her significant contribution to basic science of stroke research.

Congratulation from the whole SVDs@target-Team to this great achievement, Maiken!
On 16th January 2020 the 53rd TREAT-SVDs patient was included at the University of Edinburgh. This means, that Midterm Recruitment is reached and is a big achievement for the whole SVDs@target project. Thanks to all recuiting sites for their constant effort to recruit patients - the hard work indeed pays off.

If you want to know more about our studies and how patients can participate, please visit our "For Patients"-Section (NL, EN, D) or get in contact with us via the Contact Sheet.
For this year's GA meeting we chose the wonderful city of Paris, where Prof. Anne Joutel at INSERM is based. Please read the full article here

At the 156th annual Meeting of the National Academy of Science, Mark T. Nelson from the University of Vermont, USA was elected as member in the National Academy of Science.
To become a member in the National Academy of Science you have to be nominated followed by an extensive and careful vetting process.

Marks continuous eminent research over the last decades in the field of Neuroscience granded him access to this honor. Congratulations Mark, on this great achievement!
Our partner from Utrecht distributed a Newsletter to their research participants in order to inform them about news and insights of their running clinical studies in the field of Small Vessel diseases and dementia. Please find the Newsletter here - in dutch.

As every study site is reliant on participants, this is a very nice way to keep the participants informed. In this way, they directly can see how their effort and committment helped to improve treatments, therapies or diagnostics.

For more information about the Clinical studies in the SVDs@target project, please visit our "For Patient"-section.

In spring this year, Prof. Anne Joutel received the highly renowned Brain Price.

Since 2010, the Lundbeck Foundation annually awards the largest and most respected prize in Neuroscience to one or more brain researchers who have had ground-breaking impact on brain research.
In 2019 four french researchers were awarded - amongst Anne Joutel, who works at INSERM in Paris and leads the preclinical part of WP3 "Microvascular matrisome and vascular integrity in SVDs". Anne and the other awardees were awarded for their work in elucidating the hereditary of Small Vessel Disease.

For the full press release please visit The Brain Prize webpage.

In November 2018 the Zoom@SVDs study included the 60th participant, thereby reaching its milestone for midterm recruitment. The Zoom@SVDs study is an observational study that aims to advance our understanding of Small Vessel Disease, a condition in which the small blood vessels in the brain are damaged. We do this by zooming in on the small vessels with one of the strongest MRI scanners currently available for humans, located in the UMC Utrecht.

This study builds on a collaboration between the LMU in Munich (Germany) and the UMC Utrecht (Netherlands). In order to undergo a scan in the strong MRI in Utrecht, the 28 participants that were recruited so far in Munich travelled from all over Germany to Utrecht for an additional visit. Of course, the logistics of this study are very challenging, because flight tickets, train tickets and hotels have to be arranged as well. Also, all study information needed to be officially translated from Dutch to German and the researchers in Utrecht had to refresh their German language skills. However, these joined efforts have resulted in fast recruitment with happy participants and high-quality data.

Analyses of the first patient data have just started, of which we aim to publish the first results in the coming year. Of course, we will continue our recruitment and will continue to work in close collaboration. This study builds on our dedicated participants and good teamwork; thanks to all involved!

"Small Vessels, Dementia and Chronic Diseases"

A themed collection about "Small Vessels, Dementia and Chronic Diseases" was published by the Portland Press in the Journal of Clinical Science.

This issue is the outcome of a workshop held in Glasgow 2017 with almost 30 publications including papers from four leading researchers of the SVDs@target consortium, who translate the EU-funding into visible research.

Prof. Anne Joutel from INSERM in Paris, Prof. Maiken Nedergaard from University of Copenhagen and Prof. Geert Jan Biessels from University of Utrecht contributed a paper to the collection, respectively.

Prof. Joanna Wardlaw from University of Edinburgh contributed several papers and had the honour to beginn the collection with the introductory editorial as Guest Editor.

We are happy to have such highly respected experts among us.

The Stroke Alliance For Europe (SAFE) interviewed Anna Kopczak about Small Vessel Diseases and the work of SVDs@target.


European Commission International collaboration for research in prevention of stroke and dementia launched

SVDs@target Consortium at their Kick-Off Meeting at the ISD in Munich, 22/23 February 2016
SVDs@target Consortium

An international consortium of mostly European investigators has launched a major collaborative research program to uncover mechanisms and pathways in different forms of small vessel disease.


Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical presentations. Despite this profound impact on human health, there are no treatments with proven efficacy against SVDs.


The new network “Small vessel diseases in a mechanistic perspective: Targets for Intervention in Stroke and Dementia (SVDs@target)” is funded through the European Union’s Horizon 2020 research and innovation programme and brings together top scientists with a wide range of complementary expertise. The academic institutions involved are the Ludwig-Maximilians-Universitaet (LMU, Munich, coordinating site), the University of Oxford and University of Edinburgh (UK), the University of Copenhagen (Denmark), INSERM (France), the University of Utrecht and University of Maastricht (The Netherlands), the University of Muenster and Technische Universitaet Muenchen (Germany), and the University of Vermont (US). The network further partners with the patient organisation Stroke Alliance for Europe (SAFE, Belgium), and with Arttic, a German company for project management.


SVDs@target partners have already made major progress in identifying key mechanisms underlying multiple SVDs. The new network involves basic scientists and academic clinicians and will make use of novel animal models and expertly phenotyped patient cohorts to identify key mechanisms common to multiple SVDs and determine how these mechanisms contribute to individual SVDs.


A major objective of the 5-year project is to identify common molecular, cellular, and physiological mechanisms that compromise the function of microvessels in different SVDs. The project will further determine how these common mechanistic defects cause brain damage and explore novel therapeutic approaches in experimental systems and in patients. The project will use state-of-the art technologies to enable the development of novel treatments and contribute to the prevention of stroke and dementia.


“This project comes at the right point in time. We are very excited about the opportunity and synergies that can be expected from this collaboration” says Martin Dichgans from LMU.


Tweets by SVDS@target

Publications with PubMed ID

Authors: Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI

Nature communications. 2022 Jul 6;13(1):3897

PMID: 35794106    Open Access: PMC9259669

Authors: Rudilosso S, Chui E, Stringer MS, Thrippleton M, Chappell F, Blair G, GarcÃa DJ, Doubal F, Hamilton I, Kopczak A, Ingrish M, Kerkhofs D, Backes WH, Staals J, van Oostenbrugge R, Duering M, Dichgans M, Wardlaw JM, SVDs@Target Investigators

Neurology. 2022 May 23;99(5):e440-52

PMID: 35606147    Open Access: PMC9421604

Authors: Jochems ACC, Muñoz Maniega S, Del C Valdés Hernández M, Barclay G, Anblagan D, Ballerini L, Meijboom R, Wiseman S, Taylor AM, Corley J, Chappell FM, Backhouse EV, Stringer MS, Dickie DA, Bastin ME, Deary IJ, Cox SR, Wardlaw JM

NeuroImage. Clinical. 2022;34:103019

PMID: 35490587    Open Access: PMC9062739

Authors: Klug NR, Nelson MT

Function (Oxford, England). 2022;3(1):zqab061

PMID: 35330927    Open Access: PMC8788768

Authors: Wardlaw JM, Liebeskind DS

Stroke. 2022 Apr;53(4):1399-1401

PMID: 35227078

Authors: Habota T, Sandu AL, Waiter GD, McNeil CJ, Steele JD, Macfarlane JA, Whalley HC, Valentine R, Younie D, Crouch N, Hawkins EL, Hirose Y, Romaniuk L, Milburn K, Buchan G, Coupar T, Stirling M, Jagpal B, MacLennan B, Priba L, Harris MA, Hafferty JD, Adams MJ, Campbell AI, MacIntyre DJ, Pattie A, Murphy L, Reynolds RM, Elliot R, Penton-Voak IS, Munafò MR, Evans KL, Seckl JR, Wardlaw JM, Lawrie SM, Haley CS, Porteous DJ, Deary IJ, Murray AD, McIntosh AM

Wellcome open research. 2019;4:185

PMID: 35237729    Open Access: PMC8857525

Authors: Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C

The Journal of clinical investigation. 2022 Apr 15;132(8)

PMID: 35202003    Open Access: PMC9012276

Authors: Sundaresan V, Arthofer C, Zamboni G, Dineen RA, Rothwell PM, Sotiropoulos SN, Auer DP, Tozer DJ, Markus HS, Miller KL, Dragonu I, Sprigg N, Alfaro-Almagro F, Jenkinson M, Griffanti L

Frontiers in neuroinformatics. 2021;15:777828

PMID: 35126079    Open Access: PMC8811357

Authors: Clancy U, Makin SDJ, McHutchison CA, Cvoro V, Chappell FM, Hernández MDCV, Sakka E, Doubal F, Wardlaw JM

Neurology. 2022 Apr 5;98(14):e1459-e1469

PMID: 35131905    Open Access: PMC8992602

Authors: Biesbroek JM, Biessels GJ

International journal of stroke : official journal of the International Stroke Society. 2023 Jan;18(1):36-43

PMID: 35098817    Open Access: PMC9806474

Authors: Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M

Acta neuropathologica communications. 2022 Jan 24;10(1):6

PMID: 35074002    Open Access: PMC8785498

Authors: Lee YK, Mazzucco S, Rothwell PM, Payne SJ, Webb AJS

Journal of the American Heart Association. 2022 Feb;11(3):e022865

PMID: 35043657    Open Access: PMC9238484

Authors: McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA, Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans KL, Deary IJ, Cox SR, Robinson MR, Marioni RE

Genome biology. 2022 Jan 17;23(1):26

PMID: 35039062    Open Access: PMC8762878

Authors: Arts T, Onkenhout LP, Amier RP, van der Geest R, van Harten T, Kappelle J, Kuipers S, van Osch MJP, van Bavel ET, Biessels GJ, Zwanenburg JJM, Heart-Brain Connection Consortium

Journal of magnetic resonance imaging : JMRI. 2022 Jun;55(6):1785-1794

PMID: 34792263    Open Access: PMC9298760

Authors: Arts T, Siero JCW, Biessels GJ, Zwanenburg JJM

Journal of magnetic resonance imaging : JMRI. 2021 Jan;53(1):234-241

PMID: 32810376    Open Access: PMC7754489

Authors: Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ

The Lancet. Neurology. 2021 Jun;20(6):448-459

PMID: 33901427

Authors: de Brito Robalo BM, Biessels GJ, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Yin Ka Lam B, Leemans A, Mok V, Onkenhout LP, van den Brink H, de Luca A

NeuroImage. Clinical. 2021;32:102886

PMID: 34911192    Open Access: PMC8609094

Authors: Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M

Stroke. 2022 Apr;53(4):e130-e135

PMID: 34911345

Authors: Stringer MS, Heye AK, Armitage PA, Chappell F, Valdés Hernández MDC, Makin SDJ, Sakka E, Thrippleton MJ, Wardlaw JM

NeuroImage. Clinical. 2021;32:102883

PMID: 34911189    Open Access: PMC8607271

Authors: Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flaherty K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM

Stroke. 2022 Jan;53(1):29-33

PMID: 34847709    Open Access: PMC8700302

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM, OXVASC Study Cohort

Stroke. 2022 Apr;53(4):1310-1317

PMID: 34852644    Open Access: PMC7612543

Authors: Jiménez-Sánchez L, Hamilton OKL, Clancy U, Backhouse EV, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM

Frontiers in neurology. 2021;12:756887

PMID: 34777227    Open Access: PMC8581736

Authors: Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ

Alzheimer's & dementia (Amsterdam, Netherlands). 2021;13(1):e12240

PMID: 34604499    Open Access: PMC8474123

Authors: Backhouse EV, Shenkin SD, McIntosh AM, Bastin ME, Whalley HC, Valdez Hernandez M, Muñoz Maniega S, Harris MA, Stolicyn A, Campbell A, Steele D, Waiter GD, Sandu AL, Waymont JMJ, Murray AD, Cox SR, de Rooij SR, Roseboom TJ, Wardlaw JM

Brain : a journal of neurology. 2021 Dec 31;144(12):3769-3778

PMID: 34581779    Open Access: PMC8719837

Authors: Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M

Brain : a journal of neurology. 2022 Apr 18;145(2):787-797

PMID: 34581781    Open Access: PMC9014743

Authors: Wardlaw JM, Benveniste H, Williams A

Annual review of physiology. 2022 Feb 10;84:409-434

PMID: 34699267

Authors: Malik R, Beaufort N, Frerich S, Gesierich B, Georgakis MK, Rannikmäe K, Ferguson AC, Haffner C, Traylor M, Ehrmann M, Sudlow CLM, Dichgans M

Brain : a journal of neurology. 2021 Oct 22;144(9):2670-2682

PMID: 34626176    Open Access: PMC8557338

Authors: Meschia JF, Dichgans M

Stroke. 2021 Oct;52(10):3385-3387

PMID: 34470485    Open Access: PMC8608376

Authors: Sundaresan V, Zamboni G, Dinsdale NK, Rothwell PM, Griffanti L, Jenkinson M

Medical image analysis. 2021 Dec;74:102215

PMID: 34454295    Open Access: PMC8573594

Authors: Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson MT

The Journal of clinical investigation. 2021 Sep 15;131(18)

PMID: 34351870    Open Access: PMC8439604

Authors: Dichgans M, Beaufort N, Debette S, Anderson CD

Stroke. 2021 Aug;52(9):2974-2982

PMID: 34399583    Open Access: PMC8384143

Authors: Traylor M, Malik R, Gesierich B, Dichgans M

Brain : a journal of neurology. 2022 Mar 29;145(1):295-304

PMID: 34358307

Authors: Sundaresan V, Zamboni G, Rothwell PM, Jenkinson M, Griffanti L

Medical image analysis. 2021 Oct;73:102184

PMID: 34325148    Open Access: PMC8505759

Authors: Li L, Zuurbier SM, Kuker W, Warlow CP, Rothwell PM

Stroke. 2021 Oct;52(10):3243-3248

PMID: 34233466    Open Access: PMC8478103

Authors: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ

Translational psychiatry. 2021 Jul 6;11(1):376

PMID: 34226517    Open Access: PMC8257729

Authors: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Nov;41(11):3127-3138

PMID: 34187229    Open Access: PMC8543666

Authors: Koide M, Ferris HR, Nelson MT, Wellman GC

Frontiers in physiology. 2021;12:688468

PMID: 34168571    Open Access: PMC8218876

Authors: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ

GeroScience. 2021 Aug;43(4):1643-1652

PMID: 34160780    Open Access: PMC8492799

Authors: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM

Frontiers in physiology. 2021;12:644837

PMID: 34149442    Open Access: PMC8207286

Authors: Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Malik R, Ewers M

Nature communications. 2021 Jun 22;12(1):3825

PMID: 34158479    Open Access: PMC8219708

Authors: Wiegertjes K, Dinsmore L, Drever J, Hutchison A, Stephen J, Valdés Hernández MC, Bhatnagar P, Minks DP, Rodrigues MA, Werring DJ, de Leeuw FE, Klijn CJ, Al-Shahi Salman R, White PM, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2021 Sep;92(9):950-955

PMID: 34103345

Authors: Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S

Nature communications. 2021 Jun 1;12(1):3296

PMID: 34075043    Open Access: PMC8169932

Authors: Humphreys CA, Smith C, Wardlaw JM

Neuropathology and applied neurobiology. 2021 Dec;47(7):910-930

PMID: 34037264

Authors: Hamilton O, Cox SR, Ballerini L, Bastin ME, Corley J, Gow AJ, Muñoz Maniega S, Redmond P, Valdés Hernández MDC, Wardlaw JM, Deary IJ

Neurobiology of aging. 2021 Sep;105:25-34

PMID: 34022536    Open Access: PMC8345313

Authors: Stewart CR, Stringer MS, Shi Y, Thrippleton MJ, Wardlaw JM

Frontiers in neurology. 2021;12:647848

PMID: 34017302    Open Access: PMC8129542

Authors: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M

Translational psychiatry. 2021 May 17;11(1):291

PMID: 34001857    Open Access: PMC8129147

Authors: Arts T, Meijs TA, Grotenhuis H, Voskuil M, Siero J, Biessels GJ, Zwanenburg J

Frontiers in neuroscience. 2021;15:665480

PMID: 33981198    Open Access: PMC8107291

Authors: Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews. 2022 Apr 1;102(2):1025-1151

PMID: 33949874    Open Access: PMC8897154

Authors: Sloots JJ, Biessels GJ, de Luca A, Zwanenburg JJM

NeuroImage. 2021 Aug 1;236:118078

PMID: 33878376

Authors: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM, Third International Stroke Trial Collaborators

Stroke. 2020 May;51(5):1411-1418

PMID: 32268853    Open Access: PMC7185055

Authors: Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U, Chappell FM, Brown R, Jaime Garcia D, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés-Hernández MC, Doubal FN, Wardlaw JM

Stroke. 2020 May;51(5):1503-1506

PMID: 32264759    Open Access: PMC7185057

Authors: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 27;118(17)

PMID: 33875602    Open Access: PMC8092380

Authors: Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D

Hypertension (Dallas, Tex. : 1979). 2021 Jun;77(6):2004-2013

PMID: 33813844    Open Access: PMC8115430

Authors: Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM

European stroke journal. 2021 Mar;6(1):81-88

PMID: 33817338    Open Access: PMC7995323

Authors: Kerkhofs D, Wong SM, Zhang E, Staals J, Jansen JFA, van Oostenbrugge RJ, Backes WH

Neurology. 2021 Apr 27;96(17):e2192-e2200

PMID: 33762423    Open Access: PMC8166427

Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

Frontiers in physiology. 2021;12:643468

PMID: 33716793    Open Access: PMC7947694

Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

Frontiers in neurology. 2021;12:634460

PMID: 33732208    Open Access: PMC7956970

Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort

Stroke. 2021 Apr;52(4):1330-1338

PMID: 33588593    Open Access: PMC7610951

Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

Stroke. 2021 Mar;52(3):931-936

PMID: 33535786    Open Access: PMC7903981

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

PMID: 33357428    Open Access: PMC8186543

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

PMID: 33362520    Open Access: PMC7747080

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2021 Feb;30(2):285-298

PMID: 33307988    Open Access: PMC7854491

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

PMID: 33249860    Open Access: PMC7720874

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

PMID: 33148147

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Apr;17(4):665-685

PMID: 33185327    Open Access: PMC8593445

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2021 Aug;16(6):683-691

PMID: 33167788    Open Access: PMC8366176

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun;41(6):1463-1471

PMID: 33153374    Open Access: PMC8138338

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;134(2):127-142

PMID: 33118960    Open Access: PMC7817338

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

PMID: 32999319    Open Access: PMC7528110

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

PMID: 32924935    Open Access: PMC7521922

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

PMID: 32936435    Open Access: PMC7803876

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

PMID: 32764198    Open Access: PMC7116588

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641    Open Access: PMC7660704

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

PMID: 31968102    Open Access: PMC7009571

Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

NeuroImage. 2020 Apr 15;210:116581

PMID: 31982580

Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science (New York, N.Y.). 2020 Mar 13;367(6483)

PMID: 32001524    Open Access: PMC7375109

Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

Nature communications. 2019 Dec 20;10(1):5819

PMID: 31862893    Open Access: PMC6925280