University of Edinburgh (UEDIN)

University of Edinburgh

The University of Edinburgh (UEDIN) has, since its founding been one of the largest and most successful universities in the UK and hosts one of the foremost medical institutions in the world. In the 2014 Research Excellence Framework (REF) UEDIN ranked fourth in the UK for research power, is the strongest research centre in the UK for human/animal medicine for research power and third in the UK for Neuroscience. Overall, 84% of the College of Medicine’s research is rated ‘world-leading’ or ‘internationally excellent’. Additionally, the Neuroscience submission received a 100% score for the quality of its research environment.


A major component of Edinburgh Neuroscience and College of Medicine is the Centre for Clinical Brain Sciences, with 57 Principal Investigators, including 19 Chairs, of whom more than 70% are clinicians. SVDs are major research targets of the Centre whose academic focus is the causes, consequences and treatment of major brain disorders, undertaking interdisciplinary but integrated translational research that benefits from its location in Edinburgh BioQuarter.


Also at BioQuarter is Sunergos Innovations, the University’s commercialisation arm. Sunergos Innovations is a UK leader in the successful commercialisation of the intellectual property generated from UEDIN’s world-class research, through licensing technologies to existing companies and new University spin-outs. It has established 2,487 industrial collaborations in the past five years, and has an enviable track record of successful commercialisation, including the creation of over 300 new companies; with 81% still trading.


Roles and tasks of UEDIN in SVDs@target

UEDIN will lead the human studies in WP2 (Blood brain barrier integrity & perivascular flow in SVDs) and contributes to WP7 (Dissemination and intellectual property), through Edinburgh Research and Innovation Ltd, WP3 (Microvascular matrisome), WP4 (Immune cell binding and transmigration), and substantially to WP5 (Interventions).



Key staff

Prof. Joanna Wardlaw

Professor of Applied Neuroimaging and Honorary Consultant Neuroradiologist;

    • Director Brain Research Imaging Centre and of Edinburgh Imaging;
    • Founding Director of the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration;
    • Advisor to the Scottish Government on Stroke;
    • Chair, European Stroke Organisation International Liaison Committee;
    • Member, Royal College of Radiologists Research Committee and Grants Advisory Board of the Alzheimer’s Society UK;
    • Former European Editor of Stroke (2005-2013);
    • Former member of Scottish Intercollegiate, UK and European Guideline Committees;
    • Fellow, Academy of Medical Sciences (recently stepped down from the Council) and Fellow of the Royal Society of Edinburgh

    Major field of research: SVDs, stroke treatment and prevention; randomised clinical trials; imaging in stroke diagnosis and to study pathogenesis and cost-effectiveness analyses.

    Prof. Wardlaw is a work package leader (WP2) in SVDs@target.

    SVD@target team at UEDIN

    Dr Gordon Blair
    Clinical Research Fellow

    Dr Fergus Doubal
    Researcher/Stroke physician

    Stroke Association and Garfield Weston Foundation Senior Clinical Lecturer in stroke and SVDs;
    NHS Research Scotland Fellow and Honorary Consultant Stroke Physician;
    Wellcome Trust and EPSRC-funded research on retinal findings in lacunar stroke, collaborator with Benavente, SPS3 trial.


    Expertise in clinical assessment, cognition, brain imaging (CVR, CSF pulsatility, BBB permeability).


    Dr Michael Thrippleton
    Medical Physicist

    Brain Research Imaging Centre; expert in acquisition and analysis of cerebrovascular activity and BBB imaging.


    Ms Iona Hamilton

    Ms Elaine Sandeman

    Ms Charlotte Sutherland

    Mr Stewart Wiseman

    Ms Gayle Barclay



    Tweets by SVDS@target

    Publications with PubMed ID

    Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

    Frontiers in physiology. 2021;12:643468

    PMID: 33716793    Open Access: PMC7947694

    Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

    Frontiers in neurology. 2021;12:634460

    PMID: 33732208    Open Access: PMC7956970

    Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

    Stroke. 2021 Apr;52(4):1330-1338

    PMID: 33588593

    Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

    Stroke. 2021 Mar;52(3):931-936

    PMID: 33535786    Open Access: PMC7903981

    Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

    Cell reports. 2020 Dec 22;33(12):108524

    PMID: 33357428

    Authors: van den Brink H, Weaver NA, Biessels GJ

    Case reports in neurology. 2020 Sep-Dec;12(3):416-421

    PMID: 33362520    Open Access: PMC7747080

    Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

    Lupus. 2021 Feb;30(2):285-298

    PMID: 33307988    Open Access: PMC7854491

    Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

    Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

    PMID: 33249860    Open Access: PMC7720874

    Authors: Biessels GJ

    Stroke. 2020 Dec;51(12):3487-3488

    PMID: 33148147

    Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

    Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Nov 13;

    PMID: 33185327

    Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

    International journal of stroke : official journal of the International Stroke Society. 2020 Nov 9;:1747493020971905

    PMID: 33167788

    Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020 Nov 5;:271678X20969984

    PMID: 33153374

    Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

    Chinese medical journal. 2020 Oct 6;134(2):127-142

    PMID: 33118960    Open Access: PMC7817338

    Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

    Scientific reports. 2020 Sep 30;10(1):16073

    PMID: 32999319    Open Access: PMC7528110

    Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

    eLife. 2020 Sep 14;9

    PMID: 32924935    Open Access: PMC7521922

    Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

    Translational stroke research. 2021 Feb;12(1):15-30

    PMID: 32936435    Open Access: PMC7803876

    Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

    Investigative radiology. 2021 Jan;56(1):10-19

    PMID: 32932377

    Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

    Nature communications. 2020 Sep 2;11(1):4411

    PMID: 32879313    Open Access: PMC7468152

    Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

    Theranostics. 2020;10(21):9512-9527

    PMID: 32863942    Open Access: PMC7449902

    Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

    Physiological measurement. 2020 Oct 6;41(9):095002

    PMID: 32764198    Open Access: PMC7116588

    Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

    Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

    PMID: 32627641    Open Access: PMC7660704

    Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

    Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

    PMID: 32623925    Open Access: PMC7418931

    Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

    Circulation research. 2020 Aug 28;127(6):811-823

    PMID: 32546048

    Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

    Neurology. 2020 Jul 28;95(4):e353-e361

    PMID: 32611631    Open Access: PMC7455321

    Authors: Mestre H, Mori Y, Nedergaard M

    Trends in neurosciences. 2020 Jul;43(7):458-466

    PMID: 32423764    Open Access: PMC7331945

    Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

    The Lancet. Neurology. 2020 Aug;19(8):699-710

    PMID: 32445622

    Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

    Neurology. 2020 May 26;94(21):e2258-e2269

    PMID: 32366534    Open Access: PMC7357294

    Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

    Circulation. 2020 Jun 23;141(25):2078-2094

    PMID: 32183562    Open Access: PMC7311305

    Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

    Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

    PMID: 32046744    Open Access: PMC7014736

    Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

    Brain : a journal of neurology. 2020 Feb 1;143(2):597-610

    PMID: 31968102    Open Access: PMC7009571

    Authors: Sloots JJ, Biessels GJ, Zwanenburg JJM

    NeuroImage. 2020 Apr 15;210:116581

    PMID: 31982580

    Authors: Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

    Science (New York, N.Y.). 2020 Mar 13;367(6483)

    PMID: 32001524    Open Access: PMC7375109

    Authors: Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M

    Nature communications. 2019 Dec 20;10(1):5819

    PMID: 31862893    Open Access: PMC6925280