This network brings together basic scientists and academic clinicians and will make use of novel animal models, state-of-the art technologies (e.g. proteomics & ultra-high field MRI) and expertly phenotyped patient cohorts to identify key mechanisms common to multiple SVDs and determine how these mechanisms contribute to individual SVDs.
With the better understanding of small vessel diseases SVDs@target will develop novel therapeutic treatments and finally contribute to the prevention of stroke and dementia.
|Start date:||January 1st, 2016|
|End date:||December 31st, 2021|
|Project coordinator:||Prof. Martin Dichgans, LMU München|
|Consortium:||12 partners from 7 countries|
|Total funding:||5,998,300 EUR|
Context & Background
- define common molecular, cellular, and physiological mechanisms underlying the regulation of blood flow, and barrier and clearing functions of microvessels that are comprised in different SVDs.
- determine how these common mechanistic defects intersect to drive brain parenchymal damage, which lead to stroke and dementia as the major co-morbidities.
- validate the relevance of mechanisms and biomarkers through interventions in experimental systems (isolated microvessels and in vivo) and in patients (exploratory proof of concept trials)
- Better understanding of disease pathways
- Novel mechanistic insights into normal brain physiology
- New directions for clinical research (ultra-high-field MRI at 7T, telemetric blood pressure; monitoring, measurements of BBB integrity at 3T)
- New biomarkers (blood, MRI, histo-pathology), for a group of conditions that are challenging to diagnose
- Novel targets for testing in human interventions
Studies in Humans
ZOOM@SVDs, a MRI study at ultra-high resolution (7T) to assess microvascular function and parenchymal damage
INVESTIGATE-SVDs, a MRI study at 3T to assess blood brain barrier function, microvascular function, and perivascular flow
TREAT-SVDs, an interventional study to determine the effects of different blood pressure lowering agents on microvascular function in patients with distinct SVDs