About SVDs@target

Stroke and dementia rank among the most pressing health issues in Europe. Diseases in small blood vessels, known as cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical presentations. Despite this profound impact on human health, there are no treatments with proven efficacy against SVDs.

This network brings together basic scientists and academic clinicians and will make use of novel animal models, state-of-the art technologies (e.g. proteomics & ultra-high field MRI) and expertly phenotyped patient cohorts to identify key mechanisms common to multiple SVDs and determine how these mechanisms contribute to individual SVDs.

With the better understanding of small vessel diseases SVDs@target will develop novel therapeutic treatments and finally contribute to the prevention of stroke and dementia.
SVDs@target concept

Facts

Acronym:       SVDs@target
Start date:    January 1st, 2016
Duration:    60 months
End date: December 31st, 2020
Project coordinator:    Prof. Martin Dichgans, LMU München
Consortium:   12 partners from 7 countries
Total funding:    5,998,300 EUR

 

 

Context & Background

SVDs, or cerebral microangiopathies are a major cause of stroke and the leading cause of vascular cognitive impairment and it also contributes to other disabling symptoms such as gait disturbance and late-life depression. It is associated with vascular risk factors and its prevalence strongly increases with age, however there are also rare genetic variants of these diseases. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) caused by mutations in the NOTCH3 gene, represents a pure form of SVD and has successfully been used as a model.SVDs@target partners have already made major progress in identifying key mechanisms underlying multiple SVDs. They recently identified blood pressure variability as a major independent risk factor for multiple SVDs, stroke, and dementia and illuminated the roles of the blood brain barrier and the extracellular matrix in small vessel function. Furthermore they identified novel molecular pathways (TIMP3, LTBP1, TGFß) that are shared between different SVDs pointing towards common mechanisms. This work has laid the groundwork for the identification of additional mechanisms and novel targets for the treatment and, importantly, prevention of SVDs.

Objectives

The ambition of SVDs@target is to identify key mechanisms common to multiple SVDs and to validate novel mechanisms through interventions, with the ultimate goal of reducing the burden of SVDs, stroke and dementia. More specifically, the network aims to
  • define common molecular, cellular, and physiological mechanisms underlying the regulation of blood flow, and barrier and clearing functions of microvessels that are comprised in different SVDs.
  • determine how these common mechanistic defects intersect to drive brain parenchymal damage, which lead to stroke and dementia as the major co-morbidities.
  • validate the relevance of mechanisms and biomarkers through interventions in experimental systems (isolated microvessels and in vivo) and in patients (exploratory proof of concept trials)
  
work package objectives

Expected Impacts

The five-year programme will combine pre-clinical with clinical research to gain a better understanding of the disease pathways and mechanisms common to multiple SVDs and their main comorbidities - stroke and dementia. This will offer new directions for clinical research for better prevention, health promotion, and therapy development, as well as for the management of patients with stroke and dementia.Specifically we expect the following impacts:
  • Better understanding of disease pathways
  • Novel mechanistic insights into normal brain physiology
  • New directions for clinical research (ultra-high-field MRI at 7T, telemetric blood pressure; monitoring, measurements of BBB integrity at 3T)
  • New biomarkers (blood, MRI, histo-pathology), for a group of conditions that are challenging to diagnose
  • Novel targets for testing in human interventions

Studies in Humans

A major strength of the project is the access to large, thoroughly phenotyped cohorts of patients with genetic (CADASIL, CARASIL; >200 patients, Partner 1) and sporadic (>1.000 patients, Partners 1, 5, 7 and 9) SVDs totaling more than 1.200 patients with stroke, and about 450 with dementia or other comorbidities of SVDs. Parts of the project will be performed using these pre-existing data. However, some of our analyses will require generating new data through three sub-studies with a common core data set:

ZOOM@SVDs, a MRI study at ultra-high resolution (7T) to assess microvascular function and parenchymal damage

INVESTIGATE-SVDs, a MRI study at 3T to assess blood brain barrier function, microvascular function, and perivascular flow

TREAT-SVDs, an interventional study to determine the effects of different blood pressure lowering agents on microvascular function in patients with distinct SVDs






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Tweets by SVDS@target

Publications with PubMed ID

Authors: Rudilosso S, Chui E, Stringer MS, Thrippleton M, Chappell F, Blair G, GarcÃa DJ, Doubal F, Hamilton I, Kopczak A, Ingrish M, Kerkhofs D, Backes WH, Staals J, van Oostenbrugge R, Duering M, Dichgans M, Wardlaw JM, SVDs@Target Investigators.

Neurology. 2022 May 23;

PMID: 35606147

Authors: Jochems ACC, Muñoz Maniega S, Del C Valdés Hernández M, Barclay G, Anblagan D, Ballerini L, Meijboom R, Wiseman S, Taylor AM, Corley J, Chappell FM, Backhouse EV, Stringer MS, Dickie DA, Bastin ME, Deary IJ, Cox SR, Wardlaw JM

NeuroImage. Clinical. 2022;34:103019

PMID: 35490587    Open Access: PMC9062739

Authors: Klug NR, Nelson MT

Function (Oxford, England). 2022;3(1):zqab061

PMID: 35330927    Open Access: PMC8788768

Authors: Wardlaw JM, Liebeskind DS

Stroke. 2022 Apr;53(4):1399-1401

PMID: 35227078

Authors: Habota T, Sandu AL, Waiter GD, McNeil CJ, Steele JD, Macfarlane JA, Whalley HC, Valentine R, Younie D, Crouch N, Hawkins EL, Hirose Y, Romaniuk L, Milburn K, Buchan G, Coupar T, Stirling M, Jagpal B, MacLennan B, Priba L, Harris MA, Hafferty JD, Adams MJ, Campbell AI, MacIntyre DJ, Pattie A, Murphy L, Reynolds RM, Elliot R, Penton-Voak IS, Munafò MR, Evans KL, Seckl JR, Wardlaw JM, Lawrie SM, Haley CS, Porteous DJ, Deary IJ, Murray AD, McIntosh AM

Wellcome open research. 2019;4:185

PMID: 35237729    Open Access: PMC8857525

Authors: Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C

The Journal of clinical investigation. 2022 Apr 15;132(8)

PMID: 35202003    Open Access: PMC9012276

Authors: Sundaresan V, Arthofer C, Zamboni G, Dineen RA, Rothwell PM, Sotiropoulos SN, Auer DP, Tozer DJ, Markus HS, Miller KL, Dragonu I, Sprigg N, Alfaro-Almagro F, Jenkinson M, Griffanti L

Frontiers in neuroinformatics. 2021;15:777828

PMID: 35126079    Open Access: PMC8811357

Authors: Clancy U, Makin SDJ, McHutchison CA, Cvoro V, Chappell FM, Hernández MDCV, Sakka E, Doubal F, Wardlaw JM

Neurology. 2022 Apr 5;98(14):e1459-e1469

PMID: 35131905    Open Access: PMC8992602

Authors: Biesbroek JM, Biessels GJ

International journal of stroke : official journal of the International Stroke Society. 2022 Jan 30;:17474930211073387

PMID: 35098817

Authors: Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M

Acta neuropathologica communications. 2022 Jan 24;10(1):6

PMID: 35074002    Open Access: PMC8785498

Authors: Lee YK, Mazzucco S, Rothwell PM, Payne SJ, Webb AJS

Journal of the American Heart Association. 2022 Feb;11(3):e022865

PMID: 35043657

Authors: McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA, Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans KL, Deary IJ, Cox SR, Robinson MR, Marioni RE

Genome biology. 2022 Jan 17;23(1):26

PMID: 35039062    Open Access: PMC8762878

Authors: Arts T, Onkenhout LP, Amier RP, van der Geest R, van Harten T, Kappelle J, Kuipers S, van Osch MJP, van Bavel ET, Biessels GJ, Zwanenburg JJM, Heart-Brain Connection Consortium.

Journal of magnetic resonance imaging : JMRI. 2022 Jun;55(6):1785-1794

PMID: 34792263

Authors: Arts T, Siero JCW, Biessels GJ, Zwanenburg JJM

Journal of magnetic resonance imaging : JMRI. 2021 Jan;53(1):234-241

PMID: 32810376    Open Access: PMC7754489

Authors: Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ

The Lancet. Neurology. 2021 Jun;20(6):448-459

PMID: 33901427

Authors: de Brito Robalo BM, Biessels GJ, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Yin Ka Lam B, Leemans A, Mok V, Onkenhout LP, van den Brink H, de Luca A

NeuroImage. Clinical. 2021;32:102886

PMID: 34911192    Open Access: PMC8609094

Authors: Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M

Stroke. 2022 Apr;53(4):e130-e135

PMID: 34911345

Authors: Stringer MS, Heye AK, Armitage PA, Chappell F, Valdés Hernández MDC, Makin SDJ, Sakka E, Thrippleton MJ, Wardlaw JM

NeuroImage. Clinical. 2021;32:102883

PMID: 34911189    Open Access: PMC8607271

Authors: Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flaherty K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM

Stroke. 2022 Jan;53(1):29-33

PMID: 34847709    Open Access: PMC8700302

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM, OXVASC Study Cohort.

Stroke. 2022 Apr;53(4):1310-1317

PMID: 34852644    Open Access: PMC7612543

Authors: Jiménez-Sánchez L, Hamilton OKL, Clancy U, Backhouse EV, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM

Frontiers in neurology. 2021;12:756887

PMID: 34777227    Open Access: PMC8581736

Authors: Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ

Alzheimer's & dementia (Amsterdam, Netherlands). 2021;13(1):e12240

PMID: 34604499    Open Access: PMC8474123

Authors: Backhouse EV, Shenkin SD, McIntosh AM, Bastin ME, Whalley HC, Valdez Hernandez M, Muñoz Maniega S, Harris MA, Stolicyn A, Campbell A, Steele D, Waiter GD, Sandu AL, Waymont JMJ, Murray AD, Cox SR, de Rooij SR, Roseboom TJ, Wardlaw JM

Brain : a journal of neurology. 2021 Dec 31;144(12):3769-3778

PMID: 34581779    Open Access: PMC8719837

Authors: Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M

Brain : a journal of neurology. 2022 Apr 18;145(2):787-797

PMID: 34581781    Open Access: PMC9014743

Authors: Wardlaw JM, Benveniste H, Williams A

Annual review of physiology. 2022 Feb 10;84:409-434

PMID: 34699267

Authors: Malik R, Beaufort N, Frerich S, Gesierich B, Georgakis MK, Rannikmäe K, Ferguson AC, Haffner C, Traylor M, Ehrmann M, Sudlow CLM, Dichgans M

Brain : a journal of neurology. 2021 Oct 22;144(9):2670-2682

PMID: 34626176    Open Access: PMC8557338

Authors: Meschia JF, Dichgans M

Stroke. 2021 Oct;52(10):3385-3387

PMID: 34470485    Open Access: PMC8608376

Authors: Sundaresan V, Zamboni G, Dinsdale NK, Rothwell PM, Griffanti L, Jenkinson M

Medical image analysis. 2021 Dec;74:102215

PMID: 34454295    Open Access: PMC8573594

Authors: Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson MT

The Journal of clinical investigation. 2021 Sep 15;131(18)

PMID: 34351870    Open Access: PMC8439604

Authors: Dichgans M, Beaufort N, Debette S, Anderson CD

Stroke. 2021 Aug;52(9):2974-2982

PMID: 34399583    Open Access: PMC8384143

Authors: Traylor M, Malik R, Gesierich B, Dichgans M

Brain : a journal of neurology. 2022 Mar 29;145(1):295-304

PMID: 34358307

Authors: Sundaresan V, Zamboni G, Rothwell PM, Jenkinson M, Griffanti L

Medical image analysis. 2021 Oct;73:102184

PMID: 34325148    Open Access: PMC8505759

Authors: Li L, Zuurbier SM, Kuker W, Warlow CP, Rothwell PM

Stroke. 2021 Oct;52(10):3243-3248

PMID: 34233466    Open Access: PMC8478103

Authors: Hamilton OKL, Cox SR, Okely JA, Conte F, Ballerini L, Bastin ME, Corley J, Taylor AM, Page D, Gow AJ, Muñoz Maniega S, Redmond P, Valdés-Hernández MDC, Wardlaw JM, Deary IJ

Translational psychiatry. 2021 Jul 6;11(1):376

PMID: 34226517    Open Access: PMC8257729

Authors: Zwartbol MH, Rissanen I, Ghaznawi R, de Bresser J, Kuijf HJ, Blom K, Witkamp TD, Koek HL, Biessels GJ, Hendrikse J, Geerlings MI

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Nov;41(11):3127-3138

PMID: 34187229    Open Access: PMC8543666

Authors: Koide M, Ferris HR, Nelson MT, Wellman GC

Frontiers in physiology. 2021;12:688468

PMID: 34168571    Open Access: PMC8218876

Authors: Kerkhofs D, Wong SM, Zhang E, Uiterwijk R, Hoff EI, Jansen JFA, Staals J, Backes WH, van Oostenbrugge RJ

GeroScience. 2021 Aug;43(4):1643-1652

PMID: 34160780    Open Access: PMC8492799

Authors: Stringer MS, Blair GW, Shi Y, Hamilton I, Dickie DA, Doubal FN, Marshall IM, Thrippleton MJ, Wardlaw JM

Frontiers in physiology. 2021;12:644837

PMID: 34149442    Open Access: PMC8207286

Authors: Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., Malik R, Ewers M

Nature communications. 2021 Jun 22;12(1):3825

PMID: 34158479    Open Access: PMC8219708

Authors: Wiegertjes K, Dinsmore L, Drever J, Hutchison A, Stephen J, Valdés Hernández MC, Bhatnagar P, Minks DP, Rodrigues MA, Werring DJ, de Leeuw FE, Klijn CJ, Al-Shahi Salman R, White PM, Wardlaw JM

Journal of neurology, neurosurgery, and psychiatry. 2021 Sep;92(9):950-955

PMID: 34103345

Authors: Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S

Nature communications. 2021 Jun 1;12(1):3296

PMID: 34075043    Open Access: PMC8169932

Authors: Humphreys CA, Smith C, Wardlaw JM

Neuropathology and applied neurobiology. 2021 Dec;47(7):910-930

PMID: 34037264

Authors: Hamilton O, Cox SR, Ballerini L, Bastin ME, Corley J, Gow AJ, Muñoz Maniega S, Redmond P, Valdés Hernández MDC, Wardlaw JM, Deary IJ

Neurobiology of aging. 2021 Sep;105:25-34

PMID: 34022536    Open Access: PMC8345313

Authors: Stewart CR, Stringer MS, Shi Y, Thrippleton MJ, Wardlaw JM

Frontiers in neurology. 2021;12:647848

PMID: 34017302    Open Access: PMC8129542

Authors: Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M

Translational psychiatry. 2021 May 17;11(1):291

PMID: 34001857    Open Access: PMC8129147

Authors: Arts T, Meijs TA, Grotenhuis H, Voskuil M, Siero J, Biessels GJ, Zwanenburg J

Frontiers in neuroscience. 2021;15:665480

PMID: 33981198    Open Access: PMC8107291

Authors: Rasmussen MK, Mestre H, Nedergaard M

Physiological reviews. 2022 Apr 1;102(2):1025-1151

PMID: 33949874    Open Access: PMC8897154

Authors: Sloots JJ, Biessels GJ, de Luca A, Zwanenburg JJM

NeuroImage. 2021 Aug 1;236:118078

PMID: 33878376

Authors: Arba F, Mair G, Phillips S, Sandercock P, Wardlaw JM, Third International Stroke Trial Collaborators.

Stroke. 2020 May;51(5):1411-1418

PMID: 32268853    Open Access: PMC7185055

Authors: Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U, Chappell FM, Brown R, Jaime Garcia D, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés-Hernández MC, Doubal FN, Wardlaw JM

Stroke. 2020 May;51(5):1503-1506

PMID: 32264759    Open Access: PMC7185057

Authors: Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT

Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 27;118(17)

PMID: 33875602    Open Access: PMC8092380

Authors: Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D

Hypertension (Dallas, Tex. : 1979). 2021 Jun;77(6):2004-2013

PMID: 33813844    Open Access: PMC8115430

Authors: Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM

European stroke journal. 2021 Mar;6(1):81-88

PMID: 33817338    Open Access: PMC7995323

Authors: Kerkhofs D, Wong SM, Zhang E, Staals J, Jansen JFA, van Oostenbrugge RJ, Backes WH

Neurology. 2021 Apr 27;96(17):e2192-e2200

PMID: 33762423    Open Access: PMC8166427

Authors: Sleight E, Stringer MS, Marshall I, Wardlaw JM, Thrippleton MJ

Frontiers in physiology. 2021;12:643468

PMID: 33716793    Open Access: PMC7947694

Authors: Valdés Hernández MDC, Grimsley-Moore T, Chappell FM, Thrippleton MJ, Armitage PA, Sakka E, Makin S, Wardlaw JM

Frontiers in neurology. 2021;12:634460

PMID: 33732208    Open Access: PMC7956970

Authors: Webb AJS, Lawson A, Mazzucco S, Li L, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Stroke. 2021 Apr;52(4):1330-1338

PMID: 33588593    Open Access: PMC7610951

Authors: Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS

Stroke. 2021 Mar;52(3):931-936

PMID: 33535786    Open Access: PMC7903981

Authors: Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports. 2020 Dec 22;33(12):108524

PMID: 33357428    Open Access: PMC8186543

Authors: van den Brink H, Weaver NA, Biessels GJ

Case reports in neurology. 2020 Sep-Dec;12(3):416-421

PMID: 33362520    Open Access: PMC7747080

Authors: Valdés Hernández MDC, Smith K, Bastin ME, Nicole Amft E, Ralston SH, Wardlaw JM, Wiseman SJ

Lupus. 2021 Feb;30(2):285-298

PMID: 33307988    Open Access: PMC7854491

Authors: Webb AJS, Lawson A, Wartolowska K, Mazzucco S, Rothwell PM

Hypertension (Dallas, Tex. : 1979). 2021 Jan;77(1):193-201

PMID: 33249860    Open Access: PMC7720874

Authors: Biessels GJ

Stroke. 2020 Dec;51(12):3487-3488

PMID: 33148147

Authors: Hamilton OKL, Backhouse EV, Janssen E, Jochems ACC, Maher C, Ritakari TE, Stevenson AJ, Xia L, Deary IJ, Wardlaw JM

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Apr;17(4):665-685

PMID: 33185327    Open Access: PMC8593445

Authors: Webb AJ, Lawson A, Mazzucco S, Li L, Rothwell PM

International journal of stroke : official journal of the International Stroke Society. 2021 Aug;16(6):683-691

PMID: 33167788    Open Access: PMC8366176

Authors: Webb AJ, Lawson A, Li L, Mazzucco S, Rothwell PM, Oxford Vascular Study Phenotyped Cohort.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 Jun;41(6):1463-1471

PMID: 33153374    Open Access: PMC8138338

Authors: Clancy U, Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM

Chinese medical journal. 2020 Oct 6;134(2):127-142

PMID: 33118960    Open Access: PMC7817338

Authors: Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports. 2020 Sep 30;10(1):16073

PMID: 32999319    Open Access: PMC7528110

Authors: Cleary CM, Moreira TS, Takakura AC, Nelson MT, Longden TA, Mulkey DK

eLife. 2020 Sep 14;9

PMID: 32924935    Open Access: PMC7521922

Authors: Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM

Translational stroke research. 2021 Feb;12(1):15-30

PMID: 32936435    Open Access: PMC7803876

Authors: Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA

Investigative radiology. 2021 Jan;56(1):10-19

PMID: 32932377

Authors: Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications. 2020 Sep 2;11(1):4411

PMID: 32879313    Open Access: PMC7468152

Authors: Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S

Theranostics. 2020;10(21):9512-9527

PMID: 32863942    Open Access: PMC7449902

Authors: Lee YK, Rothwell PM, Payne SJ, Webb AJS

Physiological measurement. 2020 Oct 6;41(9):095002

PMID: 32764198    Open Access: PMC7116588

Authors: Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M

Journal of the American Heart Association. 2020 Jul 21;9(14):e016773

PMID: 32627641    Open Access: PMC7660704

Authors: Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M

Hypertension (Dallas, Tex. : 1979). 2020 Sep;76(3):953-961

PMID: 32623925    Open Access: PMC7418931

Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M

Circulation research. 2020 Aug 28;127(6):811-823

PMID: 32546048

Authors: Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M

Neurology. 2020 Jul 28;95(4):e353-e361

PMID: 32611631    Open Access: PMC7455321

Authors: Mestre H, Mori Y, Nedergaard M

Trends in neurosciences. 2020 Jul;43(7):458-466

PMID: 32423764    Open Access: PMC7331945

Authors: Biessels GJ, Nobili F, Teunissen CE, Simó R, Scheltens P

The Lancet. Neurology. 2020 Aug;19(8):699-710

PMID: 32445622

Authors: Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F, Dickie DA, Andrews P, Marshall I, Doubal FN, Wardlaw JM

Neurology. 2020 May 26;94(21):e2258-e2269

PMID: 32366534    Open Access: PMC7357294

Authors: Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A

Circulation. 2020 Jun 23;141(25):2078-2094

PMID: 32183562    Open Access: PMC7311305

Authors: Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR

Fluids and barriers of the CNS. 2020 Feb 11;17(1):15

PMID: 32046744    Open Access: PMC7014736

Authors: Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M

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